INT235362

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood cells 2
embryos 1
ventricular zone 1
erythroblasts 1
olfactory bulb 1
SNORA73A (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 29.96 Quite Low
Spinal cord 4 28.48 Quite Low
Hippocampus 33 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
GABAergic 7 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 191 100.00 Very High Very High Very High
Hematological Disease 220 98.16 Very High Very High Very High
Cleidocranial Dysplasia 10 98.12 Very High Very High Very High
Anaemia 50 94.44 High High
Targeted Disruption 130 83.84 Quite High
Pancytopenia 35 82.40 Quite High
Aplastic Anemia 25 80.40 Quite High
Myelodysplastic Syndromes 30 79.12 Quite High
Congenital Anomalies 40 77.04 Quite High
Death 21 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overexpression of Bcl-2 or E1B-19K was also found to counteract the reduction in the number of blood cells due to cytopenia.
Gene_expression (overexpression) of E1B in blood cells
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.69 Pain Relevance 0
Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the decreased blood cells numbers caused by zTERT knockdown, but not the impaired blood cell differentiation.
Gene_expression (overexpression) of E1B in blood cell associated with apoptosis
2) Confidence 0.75 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2561060 Disease Relevance 0.61 Pain Relevance 0
However, neither Bcl-2, E1B-19K overexpression, nor p53 deficiency, could restore blood cell dysplasia, which was evidenced by the presence of immature erythrocytes (erythroblasts) and anemia (data not shown for Bcl-2 and E1B-19K).
Gene_expression (overexpression) of E1B in erythroblasts associated with anaemia and cleidocranial dysplasia
3) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.59 Pain Relevance 0
By E17.5, survivin was additionally expressed in the rostral migratory stream (RMS) and at the center of the olfactory bulb (OB) (Figure 1G, I, K).
Gene_expression (expressed) of E17 in olfactory bulb
4) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.16 Pain Relevance 0
By E17, NFIX was detected in the IGG, GW and the ventricular zone (Fig. 8B), and by E18 NFIX was expressed in the regions containing all four midline glial populations and in the ventricular zone (Fig. 8C).
Gene_expression (detected) of E17 in ventricular zone
5) Confidence 0.65 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.08 Pain Relevance 0
Importantly, none of the interventions (p53 deficiency, Bcl-2, and E1B-19K) used in our present experiments that inhibit apoptosis were capable of restoring the insufficient differentiation and maturation of erythrocytes in the zTERT morphants (Figure 5E, and data not shown), suggesting that TERT is an essential component of certain processes underlying hematopoietic cell differentiation, regardless of the survival pathways that may be initiated.


Gene_expression (deficiency) of E1B in hematopoietic cell associated with apoptosis
6) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.65 Pain Relevance 0
We are currently examining in more detail both the Nfix mRNA and protein expression patterns from E12–E17 to resolve these possible discrepancies.
Gene_expression (expression) of E17
7) Confidence 0.58 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.38 Pain Relevance 0
The cytopenic phenotype, but not impaired differentiation, in the zTERT-deficient embryos is significantly reduced by the loss of p53 as well as by the expression of the anti-apoptotic proteins Bcl-2 and E1B-19K.
Gene_expression (expression) of E1B in embryos associated with apoptosis
8) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.93 Pain Relevance 0

General Comments

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