INT235397

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGDR) signal transducer activity (PTGDR)
Anatomy Link Frequency
striatum 2
PTGDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 14 100.00 Very High Very High Very High
antidepressant 19 78.40 Quite High
Ventral tegmentum 1 73.20 Quite High
5HT 141 72.88 Quite High
Nucleus accumbens 1 68.96 Quite High
Anterior cingulate cortex 6 60.64 Quite High
agonist 15 23.88 Low Low
Kinase C 13 5.00 Very Low Very Low Very Low
Raphe 9 5.00 Very Low Very Low Very Low
amygdala 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 89 93.76 High High
Tics 1 80.56 Quite High
Generalized Anxiety Disorder 1 8.40 Low Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low
Obsessive-compulsive Disorder 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Vomiting 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This might reflect a compensatory mechanism resulting from higher synaptic concentrations of dopamine in the striatum, leading to an elevation in the dopamine transporter and to a down-regulation of the D2 receptor.
Positive_regulation (leading) of Negative_regulation (regulation) of D2 receptor in striatum associated with dopamine
1) Confidence 0.03 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.53 Pain Relevance 0.53

General Comments

This test has worked.

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