INT235397

Context Info Confidence 0.03 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.53

plasma membrane (PTGDR) signal transducer activity (PTGDR)

Anatomy Link Frequency striatum 2 PTGDR (Homo sapiens)

Pain Link Frequency Relevance Heat Dopamine 14 100.00 antidepressant 19 78.40 Ventral tegmentum 1 73.20 5HT 141 72.88 Nucleus accumbens 1 68.96 Anterior cingulate cortex 6 60.64 agonist 15 23.88 Kinase C 13 5.00 Raphe 9 5.00 amygdala 6 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 89 93.76 Tics 1 80.56 Generalized Anxiety Disorder 1 8.40 Congenital Anomalies 7 5.00 Obsessive-compulsive Disorder 6 5.00 Cognitive Disorder 2 5.00 Depression 1 5.00 Vomiting 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This might reflect a compensatory mechanism resulting from higher synaptic concentrations of dopamine in the striatum, leading to an elevation in the dopamine transporter and to a down-regulation of the D2 receptor.

Positive_regulation (leading) of Negative_regulation (regulation) of D2 receptor in striatum associated with dopamine

1) Confidence 0.03 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.53 Pain Relevance 0.53

General Comments

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