INT235399

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.08
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGDR) signal transducer activity (PTGDR)
Anatomy Link Frequency
basal ganglia 2
PTGDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 25 100.00 Very High Very High Very High
Opioid 5 99.18 Very High Very High Very High
imagery 33 98.16 Very High Very High Very High
narcan 3 94.80 High High
Pain 126 92.84 High High
antidepressant 19 90.40 High High
Nucleus accumbens 26 87.08 High High
5HT 141 84.88 Quite High
rapifen 1 84.48 Quite High
Analgesic 19 84.04 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 89 98.86 Very High Very High Very High
Pain 155 92.84 High High
Tics 1 92.56 High High
Hyperalgesia 4 90.52 High High
Congenital Anomalies 9 43.56 Quite Low
Post-traumatic Stress Disorder 2 38.00 Quite Low
Sleep Disorders 3 31.08 Quite Low
Disease 11 26.24 Quite Low
Headache 1 18.84 Low Low
Burning Mouth Syndrome 1 12.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioids may produce changes in the BG including increases in D2 receptor binding [88].
Positive_regulation (increases) of D2 receptor Binding (binding) of associated with opioid
1) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2883978 Disease Relevance 0.42 Pain Relevance 1.82
Second, a disturbance in dopaminergic function seems to be observed in OCD, as supported by recent neuroimaging studies showing an increase in dopamine transporter binding along with lowered levels of dopaminergic D2 receptor binding in the basal ganglia of patients with OCD (Kim et al 2003; Denys et al 2004).
Positive_regulation (increase) of D2 receptor Binding (binding) of in basal ganglia associated with dopamine and anxiety disorder
2) Confidence 0.03 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.66 Pain Relevance 0.51

General Comments

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