INT235401

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.20
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.69
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
platelet 2
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 12 98.88 Very High Very High Very High
agonist 183 98.80 Very High Very High Very High
antidepressant 19 97.32 Very High Very High Very High
Kinase C 18 96.12 Very High Very High Very High
5HT 141 92.28 High High
headache 2 76.88 Quite High
potassium channel 2 76.76 Quite High
cytokine 1 76.48 Quite High
adenocard 9 75.08 Quite High
depression 3 7.44 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 12 99.36 Very High Very High Very High
Anxiety Disorder 89 96.60 Very High Very High Very High
Apoptosis 6 86.16 High High
Stress 7 77.52 Quite High
Vomiting 3 77.52 Quite High
Headache 2 76.88 Quite High
Diuresis 2 75.76 Quite High
Bordatella Infection 2 73.40 Quite High
Convulsion 2 65.12 Quite High
Overdose 2 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Propofol reduces the production of IP3 and can thus act as a calcium blocker preventing the entry of calcium into the vasodilatation pathway (18).
Negative_regulation (reduces) of Gene_expression (production) of IP3 associated with increased venous pressure under development
1) Confidence 0.20 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.35 Pain Relevance 0.23
11 suggests a reduction in IP3 levels as a result of decreased PLC?
Negative_regulation (reduction) of Gene_expression (levels) of IP3
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.27 Pain Relevance 0.04
Second, propofol reduces the production of IP3 and calcium release from intracellular stores (16, 17), but aminophylline induced Ca2+ release from intracellular stores, occurs via increased production of IP3 through G-protein-mediated activation (21, 25).
Negative_regulation (reduces) of Gene_expression (production) of IP3
3) Confidence 0.17 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.72 Pain Relevance 0.31
This could be a possible consequence of a reduction in the platelet levels of IP3, an intracellular product of the 5HT2 receptor-mediated phosphoinositide hydrolysis stimulating PKC, before returning to normal values after an eight-week SRI treatment (Delorme et al 2004).
Spec (possible) Negative_regulation (reduction) of Gene_expression (levels) of IP3 in platelet associated with kinase c
4) Confidence 0.05 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.28 Pain Relevance 0.41
While pre-incubation with U46619 almost completely inhibited IP3 generation by TP? 
Negative_regulation (inhibited) of Gene_expression (generation) of IP3
5) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.06 Pain Relevance 0.14
336 with U46619 impaired but did not abolish [Ca2+]i mobilization and IP3 generation in response to its secondary agonist stimulation (Fig. 5H and I, respectively).
Neg (not) Negative_regulation (abolish) of Gene_expression (generation) of IP3 associated with agonist
6) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox