INT23542

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Context Info
Confidence 0.22
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.67
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (B4galnt2) Golgi apparatus (B4galnt2)
Anatomy Link Frequency
NG108-15 1
B4galnt2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 4 96.16 Very High Very High Very High
opiate 2 94.80 High High
Pyramidal cell 12 77.80 Quite High
Hippocampus 10 5.00 Very Low Very Low Very Low
Limbic system 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 118 100.00 Very High Very High Very High
Disease 110 94.48 High High
Dementia 18 89.12 High High
Neurodegenerative Disease 18 86.96 High High
Neurological Disease 2 80.88 Quite High
Pick Disease Of The Brain 6 58.68 Quite High
Gauchers Disease 6 57.68 Quite High
Lewy Body Disease 12 50.00 Quite Low
Lysosome Storage Disease 4 35.12 Quite Low
Targeted Disruption 20 31.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of [GM3]:N-acetylgalactosaminyltransferase is similarly inhibited, but maximal inhibition is not observed for at least 30 min following the addition of [D-Ala2,D-Leu5]enkephalin.
Negative_regulation (inhibited) of N-acetylgalactosaminyltransferase associated with enkephalin
1) Confidence 0.22 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2420936 Disease Relevance 0 Pain Relevance 0.29
The reductions in the activity of [GM3]:N-acetylgalactosaminyltransferase that occur following treatment of NG108-15 cells with indomethacin argues for a direct role of cyclic AMP in the observed changed in [GM3]:N-acetylgalactosaminyltransferase activity.
Negative_regulation (reductions) of N-acetylgalactosaminyltransferase in NG108-15
2) Confidence 0.16 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2420936 Disease Relevance 0 Pain Relevance 0.25
The mechanisms through which levels of mTor might be upregulated and Atg7 downregulated in DLB and ?
Negative_regulation (downregulated) of DLB associated with parkinson's disease
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.83 Pain Relevance 0
Consistent with the immunohistochemical analysis (Figure 2), by immunoblot, levels of LC3 and Cathepsin D in the membrane fractions were reduced in the DLB cases compared to non-demented controls (Figure S1A, C).
Negative_regulation (reduced) of DLB associated with parkinson's disease
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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