INT235463

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HMBS) small molecule metabolic process (HMBS) nucleus (HMBS)
cytoplasm (HMBS)
Anatomy Link Frequency
synapses 2
HMBS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 46.96 Quite Low
Glutamate receptor 2 10.24 Low Low
agonist 20 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Angelman Syndrome 1 66.08 Quite High
Syndrome 2 65.08 Quite High
Intellectual Impairment 1 64.72 Quite High
Cancer 50 50.00 Quite Low
Wound Healing 2 48.16 Quite Low
INFLAMMATION 19 46.96 Quite Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UPS-dependent proteolysis, which may affect greatly the ligand-independent
Spec (may) Regulation (affect) of Protein_catabolism (proteolysis) of UPS
1) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0 Pain Relevance 0
In addition to being itself a target of UPS degradation [3], Shank1A is localized to synapses, and its accumulation requires other scaffold proteins in the PSD, including GKAP, Homer, and PSD-95 [16], [17], [25].
Regulation (target) of Protein_catabolism (degradation) of UPS in synapses
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.20 Pain Relevance 0

General Comments

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