INT235471

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 1.80
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HMBS) small molecule metabolic process (HMBS) nucleus (HMBS)
cytoplasm (HMBS)
Anatomy Link Frequency
neuronal 2
dendrites 1
Shank 1
synapses 1
HMBS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 85 92.04 High High
Inflammation 64 82.60 Quite High
Glutamate receptor 42 75.92 Quite High
depression 10 41.12 Quite Low
Kinase C 4 17.36 Low Low
tetrodotoxin 29 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
nMDA receptor 10 5.00 Very Low Very Low Very Low
Action potential 10 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pathologic Processes 8 95.80 Very High Very High Very High
Cancer 200 91.72 High High
Dyslipidemia /

Combined Dyslipidemia

4 88.16 High High
Diabetes Mellitus 8 87.48 High High
Disease 24 86.60 High High
Death 12 84.24 Quite High
Intellectual Impairment 16 83.68 Quite High
INFLAMMATION 76 82.60 Quite High
Targeted Disruption 33 72.88 Quite High
Parkinson's Disease 10 71.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
by modulating the activity of the UPS.
Regulation (modulating) of UPS
1) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.23 Pain Relevance 0.10
Controlling turnover of the receptors, the UPS
Regulation (Controlling) of UPS
2) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.18 Pain Relevance 0.07
pathways can exploit the UPS to modulate PPAR turnover and activity affecting
Regulation (modulate) of UPS
3) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.19 Pain Relevance 0.11
The ubiquitin-proteasome system (UPS) plays an important role in controlling level and activity of many nuclear receptors and transcription factors.
Regulation (orta) of UPS
4) Confidence 0.06 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2423003 Disease Relevance 0.60 Pain Relevance 0.08
While the abundance of many proteins in the PSD is regulated by UPS activity, only a small number of postsynaptic proteins have been observed to undergo activity-dependent ubiquitination, including the two abundant scaffold protein families called Shank and GKAP/SAPAP [3].
Regulation (regulated) of UPS in Shank
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
This simultaneous degradation of 19S particles and these bound E3s represents a novel mechanism of UPS regulation in mammalian cells.
Regulation (regulation) of UPS
6) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.44 Pain Relevance 0.04
Several forms of synaptic plasticity have been shown to require activity of the UPS (Fonseca et al., 2006; Hou et al., 2006; Karpova et al., 2006), and hence there is a growing interest in understanding how neuronal activity regulates different aspects of the UPS (Ehlers, 2003; Patrick et al., 2003; DiAntonio and Hicke, 2004; Bingol and Schuman, 2006; Bingol et al., 2010).
Regulation (regulates) of UPS in neuronal
7) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.07 Pain Relevance 0.03
Our findings further demonstrate that the global UPS activity of neurons can also be affected by neuronal activity.
Regulation (affected) of UPS in neuronal
8) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0
Recent studies have shown that neuronal activity influences the activity of UPS in dendrites and synapses (Bingol and Schuman, 2006; Djakovic et al., 2009).
Regulation (influences) of UPS in synapses
9) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0
Recent studies have shown that neuronal activity influences the activity of UPS in dendrites and synapses (Bingol and Schuman, 2006; Djakovic et al., 2009).
Regulation (influences) of UPS in dendrites
10) Confidence 0.00 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0

General Comments

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