INT23551

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.05
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CNDP2) peptidase activity (CNDP2) small molecule metabolic process (CNDP2)
cellular nitrogen compound metabolic process (CNDP2) cytoplasm (CNDP2)
Anatomy Link Frequency
blood 1
spinal 1
urine 1
CNDP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 55 99.84 Very High Very High Very High
qutenza 11 99.24 Very High Very High Very High
Enkephalin 29 98.96 Very High Very High Very High
antidepressant 6 98.72 Very High Very High Very High
Calcitonin gene-related peptide 13 98.50 Very High Very High Very High
bDMF 21 96.72 Very High Very High Very High
antagonist 5 94.32 High High
Serotonin 32 88.76 High High
opioid receptor 6 87.76 High High
Opioid 10 84.36 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 8 100.00 Very High Very High Very High
Depression 73 99.84 Very High Very High Very High
Coronary Artery Disease 48 92.36 High High
Cancer 6 88.48 High High
Diabetes Mellitus 16 88.04 High High
Carcinoma 1 87.00 High High
Colon Cancer 2 85.60 High High
Metastasis 1 84.84 Quite High
Disease 144 84.36 Quite High
Obesity 8 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The method consists of a combination of addition of a peptidase inhibitor, actinonin to serum and dialysis.
Negative_regulation (inhibitor) of peptidase
1) Confidence 0.38 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2710293 Disease Relevance 0 Pain Relevance 0.49
However, our data are compatible with reported decreased peptidase levels found by others in depression.
Negative_regulation (decreased) of peptidase associated with depression
2) Confidence 0.16 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC2063501 Disease Relevance 0.72 Pain Relevance 0.45
Peptidase inhibitors (phosphoramidon and captopril) were added to PSS to decrease peptide degradation.
Negative_regulation (decrease) of Peptidase
3) Confidence 0.14 Published 1997 Journal J. Surg. Res. Section Abstract Doc Link 9344713 Disease Relevance 0 Pain Relevance 0.30
However, TrkB and serpin peptidase inhibitor, clade e (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) were present in the set of 1,663 genes and located in module 1.
Negative_regulation (inhibitor) of peptidase
4) Confidence 0.14 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.61 Pain Relevance 0.59
However, some of the peaks are common Peptide increase in urine is found when break down is deficient, and the data presented agree with reports on peptidase deficiencies in depression.
Negative_regulation (deficiencies) of peptidase in urine associated with depression
5) Confidence 0.14 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC2063501 Disease Relevance 0.38 Pain Relevance 0.28
Livagen proved to be more efficient also as compared to well-known peptidase inhibitors such as puromycin, leupeptin, and D-PAM.
Negative_regulation (inhibitors) of peptidase
6) Confidence 0.11 Published 2003 Journal Izv. Akad. Nauk. Ser. Biol. Section Abstract Doc Link 12942748 Disease Relevance 0 Pain Relevance 0.63
Peptidase inhibitors, phosphoramidon (1 microM) and captopril (1 microM), were added to PSS to decrease peptide degradation.
Negative_regulation (decrease) of Peptidase
7) Confidence 0.09 Published 2000 Journal J Cardiovasc Surg (Torino) Section Body Doc Link 11052278 Disease Relevance 0 Pain Relevance 0
Ang 1-7 was released (88% to 100%) by a metallopeptidase, as established with peptidase inhibitors.
Negative_regulation (inhibitors) of peptidase
8) Confidence 0.07 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0.03
The potentiating effect of CGRP was unaffected by in vitro capsaicin pretreatment (10 microM for 15 min), peptidase inhibitors (captopril, bestatin and thiorphan, 1 microM each), apamin (0.3 microM) plus L-nitroarginine (L-NOARG, 100 microM) and by the CGRP1 receptor antagonist, the C-terminal fragment CGRP(8-37) (1 microM).
Negative_regulation (inhibitors) of peptidase associated with qutenza, antagonist and calcitonin gene-related peptide
9) Confidence 0.05 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9226396 Disease Relevance 0 Pain Relevance 0.58
In both cell lines, a significant suppression of cell growth by a combination of peptidase inhibitors and Met-E, compared with cells exposed to the peptide alone and cells grown in the absence of Met-E, was observed.
Negative_regulation (inhibitors) of peptidase
10) Confidence 0.05 Published 2005 Journal J. Pept. Sci. Section Abstract Doc Link 15685713 Disease Relevance 0.41 Pain Relevance 0.13
Senescent cells showed significant downregulation of three genes related to apoptosis: BCL2/adenovirus E1B interacting proteins 2 and 3, and apoptotic peptidase activating factor 1.
Negative_regulation (downregulation) of peptidase associated with apoptosis
11) Confidence 0.04 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.31 Pain Relevance 0.06
Inhibition of peptidase by i.v.t. aprotinin and bacitracin does not prevent the spinal release of Met-enkephalin induced by i.v.t. beta-endorphin.
Negative_regulation (Inhibition) of peptidase in spinal associated with enkephalin
12) Confidence 0.03 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2420969 Disease Relevance 0 Pain Relevance 1.51
In men also a variant in the serpin peptidase inhibitor, clade E member 1 gene was associated with mean blood pressure.
Negative_regulation (inhibitor) of peptidase in blood
13) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.63 Pain Relevance 0

General Comments

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