INT235512

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.76
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
macrophages 1
liver 1
muscle 1
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 120 95.44 Very High Very High Very High
agonist 18 85.92 High High
alcohol 6 78.44 Quite High
Inflammation 92 50.00 Quite Low
Inflammatory response 38 6.40 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
IPN 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 97.76 Very High Very High Very High
Disorder Of Lipid Metabolism 37 96.00 Very High Very High Very High
Atherosclerosis 163 95.40 Very High Very High Very High
Systemic Lupus Erythematosus 1 94.44 High High
Hepatocellular Cancer 10 86.28 High High
Hepatitis C Virus Infection 2 83.52 Quite High
Hepatitis 4 83.00 Quite High
Atherosclerotic Plaque 32 79.40 Quite High
Liver Disease 12 79.00 Quite High
Obesity 42 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-mediated suppression of LPL gene transcription.
Transcription (transcription) of LPL gene
1) Confidence 0.42 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.06 Pain Relevance 0.03
-mediated suppression of LPL gene transcription, the action of a plasmid construct specifying for a DN form of CK2-?
Transcription (transcription) of LPL gene
2) Confidence 0.42 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
-mediated inhibition of LPL enzymatic activity and mRNA expression in J774.2 macrophages [14].
Transcription (expression) of LPL in macrophages
3) Confidence 0.40 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
These cells were therefore employed to delineate the signalling pathways underlying inhibition of LPL gene transcription by IFN-?.
Transcription (transcription) of LPL gene
4) Confidence 0.40 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
The phosphoinositide-3-kinase (PI3K) pathway is also involved in the regulation of LPL gene transcription through Sp1/Sp3
Transcription (transcription) of LPL gene
5) Confidence 0.40 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
-mediated inhibition of LPL gene transcription
Transcription (transcription) of LPL gene
6) Confidence 0.40 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
on LPL gene transcription is not mediated at the level of Sp1/Sp3 DNA binding
Transcription (transcription) of LPL gene
7) Confidence 0.31 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
The purpose of this study was to investigate the signalling pathways underlying inhibition of LPL gene transcription via Sp1 and Sp3.


Transcription (transcription) of LPL gene
8) Confidence 0.31 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.46 Pain Relevance 0.05
LPL activity is significantly decreased with the progression of the disease due
Transcription (activity) of LPL associated with disease
9) Confidence 0.12 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.82 Pain Relevance 0
upregulates lipoprotein lipase transcription in liver and muscle and this leads to increased TG hydrolysis.
Transcription (transcription) of lipoprotein lipase in muscle
10) Confidence 0.10 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.71 Pain Relevance 0.12
upregulates lipoprotein lipase transcription in liver and muscle and this leads to increased TG hydrolysis.
Transcription (transcription) of lipoprotein lipase in liver
11) Confidence 0.03 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.71 Pain Relevance 0.12

General Comments

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