INT235515

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.19
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Anatomy Link Frequency
hearts 2
Renbp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 87 100.00 Very High Very High Very High
cytokine 51 88.92 High High
imagery 25 52.08 Quite High
Kinase C 36 32.40 Quite Low
chemokine 10 15.76 Low Low
Transcranial magnetic stimulation 1 5.04 Very Low Very Low Very Low
Central nervous system 28 5.00 Very Low Very Low Very Low
Hippocampus 20 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 2 100.00 Very High Very High Very High
Diabetes Mellitus 254 99.84 Very High Very High Very High
Atherosclerosis 138 97.60 Very High Very High Very High
Thrombosis 4 96.36 Very High Very High Very High
INFLAMMATION 97 95.72 Very High Very High Very High
Increased Venous Pressure Under Development 40 95.16 Very High Very High Very High
Atherosclerotic Plaque 56 91.28 High High
Myeloid Leukemia 33 87.72 High High
Insulin Resistance 14 87.04 High High
Targeted Disruption 67 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Note that this difference in RT is not due to a difference in the movement speed of the hands since SRT for the left and right hand were equivalent within each age group (young: left?
Positive_regulation (equivalent) of Gene_expression (group) of age
1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0.14 Pain Relevance 0.03
Furthermore, AGE products promote vascular inflammation and induce ROS accumulation, and both of these processes contribute to endothelial dysfunction via inhibition of NO production.
Positive_regulation (induce) of Gene_expression (products) of AGE associated with inflammation and vasculitis
2) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.33 Pain Relevance 0.21
The accumulation of AGE products in diabetes impairs EC function in animal models.
Positive_regulation (accumulation) of Gene_expression (products) of AGE associated with diabetes mellitus
3) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.20 Pain Relevance 0.21
Consistent with increased AGE ligand levels in the diabetic heart, a significant increase in RAGE antigen by Western blotting was observed in diabetic compared with nondiabetic hearts (P < 0.05; Fig. 4A).
Positive_regulation (increased) of Gene_expression (levels) of AGE in hearts associated with diabetes mellitus
4) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.29 Pain Relevance 0
have confirmed the expression of AGE, as well as AGE receptors within
Positive_regulation (confirmed) of Gene_expression (expression) of AGE
5) Confidence 0.02 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.72 Pain Relevance 0.04
AGE products stimulate the upregulation of
Positive_regulation (stimulate) of Gene_expression (products) of AGE
6) Confidence 0.02 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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