INT235516

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.04
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
Dendritic cell 4
monocyte 2
T cells 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 84 100.00 Very High Very High Very High
Inflammatory response 47 95.56 Very High Very High Very High
Inflammation 176 93.48 High High
rheumatoid arthritis 53 86.08 High High
Inflammatory mediators 7 86.00 High High
methotrexate 1 76.48 Quite High
Leflunomide 1 50.12 Quite High
metalloproteinase 14 49.40 Quite Low
chemokine 11 36.88 Quite Low
Bile 106 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 218 95.20 Very High Very High Very High
Hypersensitivity 18 94.68 High High
Atherosclerosis 67 94.08 High High
Targeted Disruption 8 92.08 High High
Obstructive Jaundice 10 89.68 High High
Rheumatoid Arthritis 53 86.08 High High
Stress 25 85.68 High High
Infection 24 81.64 Quite High
Cirrhosis 48 76.96 Quite High
Cholestasis 66 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, conditional deletion of SHIP-1 in T cells resulted in reduced Th2 responses to nitrophenylacetyl hapten conjugated to chicken ?
Positive_regulation (resulted) of Localization (responses) of Th2 in T cells
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.53 Pain Relevance 0.12
balance between Th1 and Th2 immune responses appears to be controlled by
Positive_regulation (balance) of Localization (responses) of Th2
2) Confidence 0.07 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.44 Pain Relevance 0.11
Dendritic cell differentiation in a cholestatic hepatic environment may lead to Th2 polarization and secretion of IL4 and IL10, rather than IFN?
Spec (may) Positive_regulation (lead) of Localization (polarization) of Th2 in Dendritic cell
3) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.88 Pain Relevance 0.18
Dendritic cell differentiation in a cholestatic hepatic environment may lead to Th2 polarization and secretion of IL4 and IL10, rather than IFN?
Positive_regulation (than) of Localization (polarization) of Th2 in Dendritic cell
4) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.88 Pain Relevance 0.18
Finally, reports have suggested that glucocorticoids inhibit cytokine expression indirectly through promotion of a Th2 cytokine secretion profile, presumably by their action on monocyte activation [91].
Positive_regulation (promotion) of Localization (secretion) of Th2 in monocyte associated with cytokine
5) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.30 Pain Relevance 0.39

General Comments

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