INT235518

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.35
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
macrophages 2
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 77 91.80 High High
Inflammation 44 5.00 Very Low Very Low Very Low
Inflammatory response 17 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
IPN 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 29 98.84 Very High Very High Very High
Atherosclerosis 122 95.40 Very High Very High Very High
Systemic Lupus Erythematosus 1 94.44 High High
Atherosclerotic Plaque 28 79.40 Quite High
Obesity 10 71.24 Quite High
Diabetes Mellitus 6 70.76 Quite High
Cancer 6 68.48 Quite High
Necrosis 6 67.92 Quite High
Disorder Of Lipid Metabolism 13 66.32 Quite High
Autoimmune Disease 2 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-mediated suppression of LPL gene transcription, the action of a plasmid construct specifying for a DN form of CK2-?
Negative_regulation (suppression) of Transcription (transcription) of LPL gene
1) Confidence 0.34 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
-mediated suppression of LPL gene transcription.
Negative_regulation (suppression) of Transcription (transcription) of LPL gene
2) Confidence 0.34 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.06 Pain Relevance 0.03
The purpose of this study was to investigate the signalling pathways underlying inhibition of LPL gene transcription via Sp1 and Sp3.


Spec (investigate) Negative_regulation (inhibition) of Transcription (transcription) of LPL gene
3) Confidence 0.25 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.46 Pain Relevance 0.05
-mediated inhibition of LPL gene transcription
Negative_regulation (inhibition) of Transcription (transcription) of LPL gene
4) Confidence 0.25 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
-mediated inhibition of LPL enzymatic activity and mRNA expression in J774.2 macrophages [14].
Negative_regulation (inhibition) of Transcription (expression) of LPL in macrophages
5) Confidence 0.25 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
LPL activity is significantly decreased with the progression of the disease due
Negative_regulation (decreased) of Transcription (activity) of LPL associated with disease
6) Confidence 0.07 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.83 Pain Relevance 0

General Comments

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