INT235549

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 8.61
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) lysosome (Ctsb) cytoplasm (Ctsb)
Anatomy Link Frequency
aorta 1
extracellular matrix 1
Ctsb (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 14 100.00 Very High Very High Very High
Inflammation 37 80.32 Quite High
metalloproteinase 19 68.12 Quite High
cytokine 20 37.88 Quite Low
Central nervous system 4 16.64 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
potassium channel 4 5.00 Very Low Very Low Very Low
Inward rectifier potassium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 392 99.84 Very High Very High Very High
Stomach Cancer 58 99.84 Very High Very High Very High
Cancer 566 99.26 Very High Very High Very High
Cytomegalovirus Infection 12 98.62 Very High Very High Very High
Adhesions 192 96.32 Very High Very High Very High
Metastasis 39 95.04 Very High Very High Very High
Glioblastoma 44 94.44 High High
Atherosclerosis 84 93.56 High High
Targeted Disruption 42 91.92 High High
Anaplastic Astrocytoma 8 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding is consistent with the eEPC transcriptome profile that indicated high expression of lysosome enzymes such as lysozyme (LYZ), cathepsins (CTSB, CTSD, CTSH, CTSL1), acid phosphatase (ACP2, ACP5), acid lipase (LIPA), and ?
Gene_expression (expression) of CTSB
1) Confidence 0.58 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0
Xenografts were transfected with SV-sh (scrambled vector), M-sh (MMP-9), U-sh (uPAR), C-sh (cathepsin B), MU-sh (MMP-9 and uPAR) or MC-sh (MMP-9 and cathepsin B) shRNA expressing plasmids using Fugene® HD reagent (Roche Diagnostics, Indianapolis, IN) as per the manufacturer's instructions.
Gene_expression (expressing) of cathepsin B
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.30 Pain Relevance 0
Cathepsin-B gene expression in apoE?
Gene_expression (expression) of Cathepsin-B gene
3) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.60 Pain Relevance 0
There was a trend toward increased expression of VCAM-1 and cathepsin-B in aorta lysates of the apoE?
Gene_expression (d increase) of cathepsin-B in aorta
4) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.40 Pain Relevance 0.04
Additionally, uPA-uPAR binding results in the expression of cathepsin B [21], another important protease involved in ECM degradation, and significantly higher levels of cathepsin B has been found in high-grade glioblastomas [22], [23].
Gene_expression (expression) of cathepsin B associated with glioblastoma
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.89 Pain Relevance 0.11
MMP-9 expressing (M-fl) plasmids in pDNR-CMV vector were designed and constructed in our laboratory whereas uPAR expressing (U-fl) and cathepsin B expressing (C-fl) plasmids were purchased from Origene (Rockville, MD).


Gene_expression (expressing) of cathepsin B associated with cytomegalovirus infection
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.27 Pain Relevance 0
MMP-9 expressing (M-fl) plasmids in pDNR-CMV vector were designed and constructed in our laboratory whereas uPAR expressing (U-fl) and cathepsin B expressing (C-fl) plasmids were purchased from Origene (Rockville, MD).


Gene_expression (expressing) of cathepsin B associated with cytomegalovirus infection
7) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.27 Pain Relevance 0
The idea of transient activation of cathepsin B by Hz is supported by the absence of cathepsin B in the supernatant of cells stimulated with Hz and the absence of lysosomal damage upon Hz treatment.
Neg (absence) Gene_expression (absence) of cathepsin B
8) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Immunohistochemical analysis of the tumor sections from control mice for cathepsin B and uPAR showed increased expression levels localized to the tumor region while the pCU-treated tumor sections revealed very little or no expression of the cathepsin B and uPAR.
Neg (no) Gene_expression (expression) of cathepsin B associated with cancer
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.69 Pain Relevance 0
Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.
Gene_expression (overexpressed) of Cathepsin B associated with glioma
10) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.85 Pain Relevance 0
Our previous work and that of others strongly suggest a relationship between the infiltrative phenotype of glioma and the expression of cathepsin B and uPAR.
Gene_expression (expression) of cathepsin B associated with glioma
11) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 1.04 Pain Relevance 0
Cathepsin B and urokinase plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas.
Gene_expression (overexpressed) of Cathepsin B associated with glioma
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.41 Pain Relevance 0
Full length cathepsin B and uPAR over expressing plasmids were purchased from Origene (Rockville, MD).
Gene_expression (expressing) of cathepsin B
13) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.16 Pain Relevance 0
Cells treated with pU (shRNA construct against uPAR) did not show appreciable difference in cathespin B expression when compared to controls (98±2%). pCU-treated (shRNA bicistronic construct against cathepsin B and uPAR) cells showed 86–91% decreased expression of cathepsin B in both SNB19 and U251 cells (p<0.01).
Gene_expression (expression) of cathepsin B
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.14 Pain Relevance 0
Various reports have demonstrated that cathepsin B and uPAR levels are overexpressed during glioma progression [28]–[30].
Gene_expression (overexpressed) of cathepsin B associated with glioma
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.78 Pain Relevance 0
Our previous work and that of others strongly suggest a relationship between the infiltrative phenotype of glioma and the expression of cathepsin B and uPAR.
Gene_expression (expression) of cathepsin B associated with glioma
16) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.44 Pain Relevance 0
Cells treated with pU (shRNA construct against uPAR) did not show appreciable difference in cathespin B expression when compared to controls (98±2%). pCU-treated (shRNA bicistronic construct against cathepsin B and uPAR) cells showed 86–91% decreased expression of cathepsin B in both SNB19 and U251 cells (p<0.01).
Gene_expression (expression) of cathepsin B
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.08 Pain Relevance 0
The expression of p27Kip1 and FOXO3a proteins were also assessed in cathepsin B and uPAR-overexpressing cells, and we found a correlation with the above mentioned results (Fig.
Gene_expression (overexpressing) of cathepsin B
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Our study identified a large number of genes associated with the extracellular matrix (SPARC, SERPINH1/HSP47, COL1A1, COL1A2, COL4A1, MMP3, TIMP1, PRSS2, CDH3, SPP1, IL8, CTSB, LUM, CEACAM, CTHRC1, SULF1, ASPN, SPON2 and CLDN18) and chemokine activity, to be differentially expressed in gastric cancers.
Gene_expression (expressed) of CTSB in extracellular matrix associated with chemokine and stomach cancer
19) Confidence 0.04 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.29 Pain Relevance 0.05

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