INT235591

Context Info Confidence 0.49 First Reported 2008 Last Reported 2008 Negated 2 Speculated 0 Reported most in Body Documents 1 Total Number 17 Disease Relevance 5.77 Pain Relevance 0

intracellular (ITSN2) cytoplasm (ITSN2)

Anatomy Link Frequency brain 3 ITSN2 (Homo sapiens)

Pain Link Frequency Relevance Heat isoflurane 34 5.00 anesthesia 17 5.00

Disease Link Frequency Relevance Heat Sleep Disorders 1479 100.00 Sleep Initiation And Maintenance Disorders 17 78.00 Stress 34 66.16 Muscle Hypotonia 34 5.00 Death 17 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A previous report in the pigeon failed to identify increases in SWA following 24 hours of sleep deprivation [31], although a significant decline in waking duration following sleep deprivation was reported, suggesting that sleep pressure was indeed higher after the deprivation.

Positive_regulation (increases) of SWA associated with sleep disorders

1) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.57 Pain Relevance 0

Further evidence for SWA as a marker of sleep need and intensity is provided by the fact that SWA increases in a regional, use-dependent manner; those brain regions that undergo the greatest waking-associated activity also show the highest regional increases in SWA during subsequent sleep [9-14].

Positive_regulation (increases) of SWA in brain

2) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.08 Pain Relevance 0

The authors reported a near elimination of sleep for more than 10 days, with no subsequent increases in either total sleep time or SWA during recovery sleep.

Neg (no) Positive_regulation (increases) of SWA

3) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.53 Pain Relevance 0

Relative to baseline, the SWA increase during recovery sleep was faster and reached significantly higher values in NREM sleep in the first hour after sleep onset.

Positive_regulation (increase) of SWA

4) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.51 Pain Relevance 0

Moreover, in the white-crowned sparrow during the migratory season, despite an average reduction in nocturnal sleep of 60%, no evidence of a compensatory increase in SWA was observed in the small amount of nocturnal sleep that was obtained [25].

Positive_regulation (increase) of SWA

5) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.14 Pain Relevance 0

Sleep deprivation results in increases in SWA during recovery sleep relative to normal physiological sleep; this phenomenon has been demonstrated in a variety of mammalian species including humans, squirrels, rats, mice and hamsters [2-8].

Positive_regulation (increases) of SWA associated with sleep disorders

6) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.16 Pain Relevance 0

The aim of the current study was therefore to ascertain whether sleep loss in the white-crowned sparrow leads to compensatory increases in SWA during the subsequent sleep period.

Positive_regulation (increases) of SWA

7) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.22 Pain Relevance 0

However, 24 hours of sleep deprivation in another avian species, the pigeon, resulted in small increases in the duration of total NREM and REM sleep in the subsequent sleep period, but no compensatory increase in SWA was reported [31].

Neg (no) Positive_regulation (increase) of SWA associated with sleep disorders

8) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.10 Pain Relevance 0

Mean SWA during drowsiness was increased, relative to the same time of day in baseline, during the first 2 hours after sleep deprivation, but its levels in recovery were never higher than those reached at sleep onset during baseline.

Positive_regulation (increased) of SWA associated with sleep disorders

9) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 1.01 Pain Relevance 0

During the migratory season, captive white-crowned sparrows reduced nocturnal sleep by ~60%, with no evidence of increased SWA in the small amount of nocturnal sleep they do obtain [25].

Positive_regulation (increased) of SWA

10) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.55 Pain Relevance 0

For instance, SWA increases locally after a learning task and is positively correlated with post-sleep performance improvement [15], suggesting that SWA may represent more than a measure of sleep need and intensity, but may in fact mediate the restorative function of NREM sleep [15-17].

Positive_regulation (increases) of SWA

11) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.07 Pain Relevance 0

Further evidence for SWA as a marker of sleep need and intensity is provided by the fact that SWA increases in a regional, use-dependent manner; those brain regions that undergo the greatest waking-associated activity also show the highest regional increases in SWA during subsequent sleep [9-14].

Positive_regulation (increases) of SWA in brain

12) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.09 Pain Relevance 0

In mammals, sleep deprivation is followed not only by an increase in SWA, but also by an increase in the duration of sleep episodes and a decrease in the number of brief awakenings [37-39].

Positive_regulation (increase) of SWA associated with sleep disorders

13) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.10 Pain Relevance 0

Recent data also suggests that SWA increases specifically in those brain regions that during waking have presumably undergone synaptic potentiation.

Positive_regulation (increases) of SWA in brain

14) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.08 Pain Relevance 0

Moreover, peak SWA in both SWS and NREM sleep increased significantly immediately following sleep deprivation relative to baseline.

Positive_regulation (increased) of SWA associated with sleep disorders

15) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2424059 Disease Relevance 0.34 Pain Relevance 0

SWA in drowsiness also significantly increased in the first 20 to 40 minutes of recovery sleep relative to baseline.

Positive_regulation (increased) of SWA associated with sleep disorders

16) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.55 Pain Relevance 0

SWA in drowsiness also significantly increased in the first 20 to 40 minutes after sleep onset.

Positive_regulation (increased) of SWA associated with sleep disorders

17) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.67 Pain Relevance 0

General Comments

This test has worked.