INT235634

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 3.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
Anatomy Link Frequency
plasma 5
adipocytes 4
Fao 1
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 46 5.00 Very Low Very Low Very Low
anesthesia 25 5.00 Very Low Very Low Very Low
imagery 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 330 99.60 Very High Very High Very High
Hepatocellular Cancer 23 99.04 Very High Very High Very High
Diabetes Mellitus 258 87.72 High High
Insulin Resistance 70 86.40 High High
Pressure And Volume Under Development 2 63.84 Quite High
Disease 41 56.16 Quite High
Frailty 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The generated genelist included several noteworthy genes like the insulin receptor (INSR), insulin receptor substrate 2 (IRS2), protein phosphatase 1 (PPP1CB), lipoprotein lipase (LPL), hexokinase 2 (HK2), phosphorylase kinase (PHKA1), forkhead box O3A (FOXO3A), histone deacetylase 7A (HDAC7A), and NADH dehydrogenase (NDUFS1) (Table 2).
Phosphorylation (phosphorylase kinase) of INSR
1) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.20 Pain Relevance 0
The generated genelist included several noteworthy genes like the insulin receptor (INSR), insulin receptor substrate 2 (IRS2), protein phosphatase 1 (PPP1CB), lipoprotein lipase (LPL), hexokinase 2 (HK2), phosphorylase kinase (PHKA1), forkhead box O3A (FOXO3A), histone deacetylase 7A (HDAC7A), and NADH dehydrogenase (NDUFS1) (Table 2).
Phosphorylation (phosphorylase kinase) of insulin receptor
2) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.20 Pain Relevance 0
The resulting signals are therefore proportional to the relative degree of phosphorylation of IR and IRS1.
Phosphorylation (phosphorylation) of IR
3) Confidence 0.31 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.15 Pain Relevance 0
To gain further insight into which mechanisms that are most active during the early events of insulin signaling, we have measured the transient phosphorylation of IR and IRS1 during the first ten minutes after a step increase in extracellular insulin concentration.
Phosphorylation (phosphorylation) of IR
4) Confidence 0.31 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.11 Pain Relevance 0
In a more recent time-course modeling of IR phosphorylation and endocytosis in Fao hepatoma cells [28], no transient phosphorylation overshoot was included, neither in the experimental data, nor in the model.
Phosphorylation (phosphorylation) of IR in Fao associated with hepatocellular cancer
5) Confidence 0.31 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.10 Pain Relevance 0
We used model-based hypothesis testing to evaluate three mechanistic explanations for this behavior: (A) phosphorylation and dephosphorylation of IR at the plasma membrane only; (B) the additional possibility for IR endocytosis; (C) the alternative additional possibility of feedback signals to IR from downstream intermediates.
Phosphorylation (dephosphorylation) of IR in plasma
6) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Abstract Doc Link PMC2424138 Disease Relevance 0.22 Pain Relevance 0
The first part reports a rapid overshoot in IR and IRS1 phosphorylation upon insulin stimulation of human fat cells.
Phosphorylation (phosphorylation) of IR in fat cells associated with obesity
7) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.10 Pain Relevance 0
The second part of the paper analyzes three biologically realistic and plausible mechanistic explanations: (A) direct phosphorylation and dephosphorylation of IR at the plasma membrane only; (B) the additional possibility of IR endocytosis; (C) the alternative additional possibility of feedback to IR from downstream intermediates.
Phosphorylation (phosphorylation) of IR in plasma
8) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.08 Pain Relevance 0
m,d), the possibility for multiple tyrosine phosphorylations of IR (?
Phosphorylation (phosphorylations) of IR
9) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
We measured phosphorylated and total IR and IRS1 by SDS-PAGE and immunoblotting.
Phosphorylation (phosphorylated) of IR
10) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.17 Pain Relevance 0
A rather general model structure that includes internalization and dephosphorylation of IR at both the plasma membrane and in the cytosol is given by ?
Phosphorylation (dephosphorylation) of IR in plasma
11) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
We used model-based hypothesis testing to evaluate three mechanistic explanations for this behavior: (A) phosphorylation and dephosphorylation of IR at the plasma membrane only; (B) the additional possibility for IR endocytosis; (C) the alternative additional possibility of feedback signals to IR from downstream intermediates.
Phosphorylation (phosphorylation) of IR in plasma
12) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Abstract Doc Link PMC2424138 Disease Relevance 0.22 Pain Relevance 0
To achieve a robust measurement signal, the extent of phosphorylation of both IR and IRS1 were divided by total amount of IR and IRS1, respectively.
Phosphorylation (phosphorylation) of IR
13) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.16 Pain Relevance 0
However, the Sedaghat model does not predict an overshoot in the IR phosphorylation, and must generally be revised to serve as a (single) explanation to our experimental data [27].
Phosphorylation (phosphorylation) of IR
14) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
The second part of the paper analyzes three biologically realistic and plausible mechanistic explanations: (A) direct phosphorylation and dephosphorylation of IR at the plasma membrane only; (B) the additional possibility of IR endocytosis; (C) the alternative additional possibility of feedback to IR from downstream intermediates.
Phosphorylation (dephosphorylation) of IR in plasma
15) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.08 Pain Relevance 0
Thus autophosphorylated, the IR is active against a set of intracellular signal mediator proteins, in particular the insulin receptor substrate-1 (IRS1), which becomes phosphorylated on tyrosine residues.
Phosphorylation (phosphorylated) of IR
16) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.41 Pain Relevance 0
Thus autophosphorylated, the IR is active against a set of intracellular signal mediator proteins, in particular the insulin receptor substrate-1 (IRS1), which becomes phosphorylated on tyrosine residues.
Phosphorylation (autophosphorylated) of IR
17) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.41 Pain Relevance 0
We examined the extent of phosphorylation of IR and IRS1 on tyrosine residues in human adipocytes.
Phosphorylation (phosphorylation) of IR in adipocytes associated with obesity
18) Confidence 0.24 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.20 Pain Relevance 0
Conversely, the insulin-controlled internalization of IR has been shown to depend on IR autophosphorylation [13],[16],[17], but to be independent of downstream activation of IRS or phosphatidylinositol-3 kinase [17].
Phosphorylation (autophosphorylation) of IR
19) Confidence 0.24 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.25 Pain Relevance 0
We measured time-courses in primary human adipocytes for the short-term phosphorylation dynamics of the insulin receptor (IR) and the IR substrate-1 in response to a step increase in insulin concentration.
Phosphorylation (phosphorylation) of IR in adipocytes associated with obesity
20) Confidence 0.24 Published 2008 Journal PLoS Computational Biology Section Abstract Doc Link PMC2424138 Disease Relevance 0.27 Pain Relevance 0

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