INT235635

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.78
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
Anatomy Link Frequency
hepatocytes 3
fat cells 3
muscle 2
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 46 88.56 High High
cytokine 46 79.64 Quite High
metalloproteinase 2 14.64 Low Low
tolerance 18 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 86 99.70 Very High Very High Very High
Metabolic Syndrome 158 98.86 Very High Very High Very High
Obesity 81 98.60 Very High Very High Very High
Diabetes Mellitus 211 98.00 Very High Very High Very High
INFLAMMATION 64 88.56 High High
Disease 42 85.20 High High
Stress 31 83.64 Quite High
Adhesions 14 53.48 Quite High
Hypertension 63 52.32 Quite High
Cardiovascular Disease 118 42.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first part reports a rapid overshoot in IR and IRS1 phosphorylation upon insulin stimulation of human fat cells.
Negative_regulation (overshoot) of Phosphorylation (phosphorylation) of IRS1 in fat cells associated with obesity
1) Confidence 0.37 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.10 Pain Relevance 0
The resulting signals are therefore proportional to the relative degree of phosphorylation of IR and IRS1.
Negative_regulation (degree) of Phosphorylation (phosphorylation) of IRS1
2) Confidence 0.37 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.15 Pain Relevance 0
Interestingly, the feedback signals do generate an overshoot in IRS1 phosphorylation.
Negative_regulation (overshoot) of Phosphorylation (phosphorylation) of IRS1
3) Confidence 0.37 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
The main cellular molecular mechanism of insulin desensitization, with consequent insulin resistance presents in MetS-patients, involves increased serine phosphorylation and decreased tyrosine phosphorylation of IRS-1.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of IRS-1 associated with metabolic syndrome and insulin resistance
4) Confidence 0.32 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.72 Pain Relevance 0
signaling, is extensively implicated in all aspects of skeletal muscle function [61], while at an individual gene level, the directional changes in ERK1/2 and MEK1/2 are consistent with the emerging mechanism through which saturated fatty acids induce muscle insulin resistance [62] and with decreased IRS-1 (insulin receptor substrate-1) phosphorylation [63] promoting the degradation of IRS-1 [64] and thus impaired insulin action.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of IRS-1 in muscle associated with insulin resistance
5) Confidence 0.20 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.77 Pain Relevance 0
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of IRS-1 in hepatocytes associated with obesity
6) Confidence 0.07 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.02 Pain Relevance 0.21
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Negative_regulation (reduction) of in adipocytes Phosphorylation (phosphorylation) of IRS-1 in hepatocytes associated with obesity
7) Confidence 0.02 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.02 Pain Relevance 0.21

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