INT23564

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Context Info
Confidence 0.50
First Reported 1983
Last Reported 2010
Negated 0
Speculated 7
Reported most in Abstract
Documents 103
Total Number 113
Disease Relevance 27.28
Pain Relevance 21.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
reticulum 6
neurons 5
external 3
myotubes 3
plasma 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 482 100.00 Very High Very High Very High
nMDA receptor 236 100.00 Very High Very High Very High
Action potential 219 100.00 Very High Very High Very High
Neurotransmitter 72 100.00 Very High Very High Very High
long-term potentiation 180 99.84 Very High Very High Very High
cINOD 409 99.56 Very High Very High Very High
Paracetamol 7 99.20 Very High Very High Very High
Neuropathic pain 54 99.00 Very High Very High Very High
substance P 44 98.92 Very High Very High Very High
antagonist 220 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Glaucoma 51 99.88 Very High Very High Very High
Ocular Hypertension 507 99.84 Very High Very High Very High
Frailty 25 99.84 Very High Very High Very High
Nervous System Injury 49 99.72 Very High Very High Very High
Necrosis 8 99.70 Very High Very High Very High
Acidosis 72 99.68 Very High Very High Very High
Neuropathic Pain 154 99.00 Very High Very High Very High
Disease 771 98.56 Very High Very High Very High
Contracture 25 98.56 Very High Very High Very High
INFLAMMATION 355 98.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our experiments show that a genetic deficiency of CAII in mice homozygous for a mutation in the Car2 gene does not alter IOP.
Negative_regulation (deficiency) of CAII associated with ocular hypertension
1) Confidence 0.50 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.90 Pain Relevance 0
Car2 deficiency does not alter IOP
Negative_regulation (deficiency) of Car2 associated with ocular hypertension
2) Confidence 0.42 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.17 Pain Relevance 0
It also is possible that CAII substantially contributes to aqueous humor secretion but that functional mouse CAIV is sufficient to prevent an effect of CAII deficiency on IOP in Car2 mutant mice.
Negative_regulation (deficiency) of CAII associated with ocular hypertension
3) Confidence 0.42 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.01 Pain Relevance 0
Thus we infer that a reduction in Ca2+ uptake in IOOA is not due to reduced Ca2+ pump levels, but rather is probably due to a functional abnormality in SERCA 1, or in phospholamban, a SERCA regulator, or alternatively to a reduced level of ATP phosphorylation.
Negative_regulation (reduced) of Ca2
4) Confidence 0.42 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.39 Pain Relevance 0.04
These results contrasted with a rapid decrease in mitochondrial Ca2+ concentration produced by a short (5 min) exposure to 500 microM t-butylhydroperoxide, a generator of free radicals.
Negative_regulation (decrease) of Ca2
5) Confidence 0.38 Published 1987 Journal Eur J Cancer Clin Oncol Section Abstract Doc Link 2439346 Disease Relevance 0.39 Pain Relevance 0.09
Daunomycin, 10(-6) M, produced 90% inhibition of the Ca2+ -dependent action potential.
Negative_regulation (inhibition) of Ca2 associated with action potential
6) Confidence 0.38 Published 1986 Journal Cancer Res. Section Abstract Doc Link 2421881 Disease Relevance 0.20 Pain Relevance 0.39
Cells exposed to 10(-5) M doxorubicin showed 88% inhibition of the Ca2+ -dependent action potential with no recovery even 10 min after removing the drug.
Negative_regulation (inhibition) of Ca2 associated with action potential
7) Confidence 0.38 Published 1986 Journal Cancer Res. Section Abstract Doc Link 2421881 Disease Relevance 0.25 Pain Relevance 0.39
The present study does not support earlier published findings, which suggested that several behaviourally active drugs produce significant decreases of brain Ca2+.
Negative_regulation (decreases) of Ca2 in brain
8) Confidence 0.38 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6419254 Disease Relevance 0.16 Pain Relevance 0.11
The day-night variation in the magnitude of the Ca2+ response was due to two cell populations, one of which exhibited an increase and the other a decrease in Ca2+ in response to muscimol.
Negative_regulation (decrease) of Ca2
9) Confidence 0.38 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12534969 Disease Relevance 0 Pain Relevance 0.19
The veratridine-induced [Ca2+]i transients were critically dependent on the influx of Ca2+ and persisted after thapsigargin inhibition of the endoplasmic reticulum Ca2+-ATPase.
Negative_regulation (inhibition) of Ca2 in reticulum
10) Confidence 0.37 Published 1999 Journal Cell. Signal. Section Abstract Doc Link 10376807 Disease Relevance 0 Pain Relevance 0.18
Effect of EFS was blocked by the selective inhibitor of N-type Ca2+ channels, ?
Negative_regulation (inhibitor) of Ca2
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659787 Disease Relevance 0.39 Pain Relevance 0.39
Inhibition of dihydropyridine-sensitive Ca2+ channels with nifedipine or PN-200-110 did not prevent [Ca2+]i elevations induced by higher concentrations of salbutamol.
Negative_regulation (Inhibition) of Ca2
12) Confidence 0.37 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10329950 Disease Relevance 0 Pain Relevance 0.16
After removal of Ca2+ with 5 mM EGTA, followed by replacement with 2.5 mM Ca2+ for 1 min, the Cu2(+)-contracture was fully restored.
Negative_regulation (removal) of Ca2 associated with contracture
13) Confidence 0.37 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2515819 Disease Relevance 1.20 Pain Relevance 0.08
However, larger current injection overcame this inhibition of Ca2+ action potentials suggesting that gabapentin did not predominantly affect L-type Ca2+ channels.
Negative_regulation (inhibition) of Ca2 associated with action potential and gabapentin
14) Confidence 0.36 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11408520 Disease Relevance 0 Pain Relevance 1.50
Thus, we postulated that, in primary IOOA, the Ca2+ storage within the sarcoplasmic reticulum is reduced due to Ca2+-ATPase inactivation, and that consequently Ca2+-release capacity is reduced.
Negative_regulation (inactivation) of Ca2 in reticulum
15) Confidence 0.36 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.30 Pain Relevance 0.03
3), completely abolished the [Ca2+]m oscillations, suggesting that they depend on neuronal activity.
Negative_regulation (abolished) of Ca2 in neuronal
16) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0.27
To test postsynaptic sensitivity to excitatory amino acid agonists, responses to bath applications were measured in VCN neurons while synaptic transmission was blocked by the removal of Ca2+ from the bath or by the addition of tetrodotoxin.
Negative_regulation (removal) of Ca2 in VCN associated with tetrodotoxin, agonist and excitatory amino acid
17) Confidence 0.33 Published 1989 Journal Brain Res. Section Abstract Doc Link 2566363 Disease Relevance 0 Pain Relevance 0.64
Ca2+ pump activity is known to be reduced in muscular dystrophy and in Brody disease.22,25 However, little information is available on the role of Ca2+ pump in ocular disease, especially in oculomotor disease, although it was reported that Ca2+ pump activity changes in lens epithelial cells after treated with an oxidant or heat.26 In the present study, Ca2+ pump levels, which is one of the factors that impacts the Ca2+ uptake rate, were assayed by western blotting for SERCA 1, a fast twitch isoform of SERCA.
Negative_regulation (reduced) of Ca2 in epithelial cells associated with frailty, disease and eye disease
18) Confidence 0.31 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.49 Pain Relevance 0.05
A selective inhibitor of Ca2+ and calmodulin dependent protein kinase II also did not affect the elevation of [Nai] induced by veratridine, but markedly diminished the elevation of [Cai] induced by depolarization either with veratridine or with high K+ (15 and 30 mM).
Negative_regulation (inhibitor) of Ca2
19) Confidence 0.31 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9580510 Disease Relevance 0 Pain Relevance 0.32
Thus, we postulated that, in primary IOOA, the Ca2+ storage within the sarcoplasmic reticulum is reduced due to Ca2+-ATPase inactivation, and that consequently Ca2+-release capacity is reduced.
Negative_regulation (reduced) of Ca2 in reticulum
20) Confidence 0.31 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.29 Pain Relevance 0.03

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