INT235655

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 13.48
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (EPHA2) plasma membrane (EPHA2)
Anatomy Link Frequency
oesophagus 2
bladder 2
EPHA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 98.12 Very High Very High Very High
Osteoarthritis 65 81.80 Quite High
cytokine 4 65.64 Quite High
anesthesia 11 30.56 Quite Low
antagonist 2 26.16 Quite Low
metalloproteinase 2 12.36 Low Low
imagery 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 6 99.98 Very High Very High Very High
Cancer 304 99.72 Very High Very High Very High
Apoptosis 19 99.48 Very High Very High Very High
Vulvar Cancer 44 99.44 Very High Very High Very High
Cervical Cancer 253 99.38 Very High Very High Very High
Ovarian Cancer 122 99.36 Very High Very High Very High
INFLAMMATION 11 98.12 Very High Very High Very High
Skin Cancer 33 97.76 Very High Very High Very High
Stomach Cancer 22 97.60 Very High Very High Very High
Bladder Cancer 11 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contrary, in our previous study of squamous cell cervical carcinomas FIGO stage I-IV we found that increased expression of EphA2 and EphrinA-1 was significantly associated with shorter overall survival in multivariate analysis 22.
Positive_regulation (increased) of Gene_expression (expression) of EphA2 associated with cervical cancer
1) Confidence 0.67 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.91 Pain Relevance 0
Increased expression of EphA2 was not of prognostic significance, whereas overexpression of EphrinA-1 (strong staining) was associated with poor survival in squamous cell cervical carcinomas FIGO stage IB in univariate analysis.
Positive_regulation (Increased) of Gene_expression (expression) of EphA2 associated with cervical cancer
2) Confidence 0.67 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.99 Pain Relevance 0
In our previous study of cervical carcinomas FIGO stage I-IV we found that increase expression of EphA2 and EphrinA-1 was significantly associated with shorter overall survival in multivariate analysis 22.
Positive_regulation (increase) of Gene_expression (expression) of EphA2 associated with cervical cancer
3) Confidence 0.67 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.07 Pain Relevance 0
EphA2 is overexpressed in a variety of human cancers, including breast 12, prostate 13, 14, oesophagus 15, renal 16, lung 17, pancreas 18 and ovarian 19, 20.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EphA2 in oesophagus associated with cancer
4) Confidence 0.67 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.02 Pain Relevance 0
However, EphA2 overexpression has been found to be associated with high cyclin A level, whereas, increase expression of EphrinA-1 correlated with high cyclin A and p21 levels in vulvar cancer 21.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EphA2 associated with vulvar cancer
5) Confidence 0.67 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.06 Pain Relevance 0
Furthermore, increase expression of both EphA2 and EphrinA-1 have been observed in vulvar carcinomas 21, cervical carcinomas 22, bladder carcinomas 23, oesophageal carcinomas 24, gastric carcinomas 25 and ovarian carcinomas 26.
Positive_regulation (increase) of Gene_expression (expression) of EphA2 in bladder associated with vulvar cancer, cervical cancer, ovarian cancer, bladder cancer, esophageal cancer and stomach cancer
6) Confidence 0.48 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.13 Pain Relevance 0
In various human cancers poor outcome for the patients has been associated with increase expression of EphA2 and EphrinA-1 16, 17, 19, 24, 26.
Positive_regulation (increase) of Gene_expression (expression) of EphA2 associated with cancer
7) Confidence 0.48 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.09 Pain Relevance 0
The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may be important factors in the development of a subset of early cervical cancers.
Positive_regulation (increased) of Gene_expression (levels) of EphA2 associated with cervical cancer and skin cancer
8) Confidence 0.45 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.89 Pain Relevance 0
The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers.
Positive_regulation (increased) of Gene_expression (levels) of EphA2 associated with cervical cancer and skin cancer
9) Confidence 0.45 Published 2008 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2424178 Disease Relevance 0.69 Pain Relevance 0
Previously, a wide range of EphA2 overexpression (34-87%) 15, 17, 19, 22, 24-26 and EphrinA-1 overexpression (41-61%) 22, 24, 26 has been reported in many other human cancer types FIGO stage I-IV, including squamous cell cervical carcinomas were 43% and 46% of the cases overexpressed EphA2 and EphrinA-1, respectively 22.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EphA2 associated with cervical cancer and cancer
10) Confidence 0.45 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.77 Pain Relevance 0
In conclusion, the increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers.
Positive_regulation (increased) of Gene_expression (levels) of EphA2 associated with cervical cancer and skin cancer
11) Confidence 0.45 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.93 Pain Relevance 0
A positive association in the expression levels of COX-2 and caveolin-1 [35], [36] or EPH receptor A2 [37] is supported by findings of other studies employing different cell types.
Positive_regulation (association) of Gene_expression (expression) of EPH receptor A2
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.91 Pain Relevance 0.32
EphA2 is a protein overexpressed by many tumor cells.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EphA2 associated with cancer
13) Confidence 0.17 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.08 Pain Relevance 0.03
Approximately 20%–25% of breast cancers overexpress human epidermal receptor type 2 (ErbB2 or HER2), which is associated with a more aggressive cancer and predicts poor clinical outcome (Slamon et al 1987).
Positive_regulation (overexpress) of Gene_expression (overexpress) of epidermal receptor type 2 associated with cancer and breast cancer
14) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727787 Disease Relevance 0.94 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox