INT235658

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.42
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (EPHA2) plasma membrane (EPHA2)
EPHA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 98.12 Very High Very High Very High
Osteoarthritis 64 81.80 Quite High
cytokine 3 58.56 Quite High
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 11 99.48 Very High Very High Very High
Cancer 61 99.16 Very High Very High Very High
INFLAMMATION 11 98.12 Very High Very High Very High
Skin Cancer 9 97.76 Very High Very High Very High
Cervical Cancer 69 96.52 Very High Very High Very High
Disease 31 94.24 High High
Vulvar Cancer 12 86.76 High High
Osteoarthritis 71 81.80 Quite High
Adenocarcinoma 3 74.76 Quite High
Small Cell Lung Carcinoma 3 73.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers.
Positive_regulation (increased) of EphA2 associated with cervical cancer and skin cancer
1) Confidence 0.67 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.93 Pain Relevance 0
The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may be important factors in the development of a subset of early cervical cancers.
Positive_regulation (increased) of EphA2 associated with cervical cancer and skin cancer
2) Confidence 0.67 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.89 Pain Relevance 0
The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers.
Positive_regulation (increased) of EphA2 associated with cervical cancer and skin cancer
3) Confidence 0.45 Published 2008 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2424178 Disease Relevance 0.69 Pain Relevance 0
A positive association in the expression levels of COX-2 and caveolin-1 [35], [36] or EPH receptor A2 [37] is supported by findings of other studies employing different cell types.
Positive_regulation (association) of EPH receptor A2
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.91 Pain Relevance 0.32

General Comments

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