INT235660

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 27
Total Number 30
Disease Relevance 23.46
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (EPHA2) plasma membrane (EPHA2)
Anatomy Link Frequency
squamous epithelium 1
oesophagus 1
bladder 1
EPHA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 97.36 Very High Very High Very High
Osteoarthritis 65 81.04 Quite High
cytokine 4 65.64 Quite High
anesthesia 27 54.88 Quite High
antagonist 2 26.16 Quite Low
metalloproteinase 2 12.36 Low Low
imagery 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 6 99.98 Very High Very High Very High
Cancer 624 99.80 Very High Very High Very High
Cervical Cancer 621 99.52 Very High Very High Very High
Vulvar Cancer 108 99.44 Very High Very High Very High
Ovarian Cancer 154 99.36 Very High Very High Very High
Apoptosis 19 98.72 Very High Very High Very High
Skin Cancer 81 97.76 Very High Very High Very High
INFLAMMATION 11 97.36 Very High Very High Very High
Stomach Cancer 54 97.20 Very High Very High Very High
Bladder Cancer 27 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of EphA2 was not of prognostic significance, whereas overexpression of EphrinA-1 (strong staining) was associated with poor survival in squamous cell cervical carcinomas FIGO stage IB in univariate analysis.
Gene_expression (expression) of EphA2 associated with cervical cancer
1) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.99 Pain Relevance 0
EphA2 and EphrinA-1 expression were defined as high when strong staining was seen in the tumor cells or, alternatively, when strong/moderate staining was identified.


Gene_expression (expression) of EphA2 associated with cancer
2) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.67 Pain Relevance 0
For EphA2 cytoplasmic expression was observed in 196/217 (90%) of the cervical cancers, whereas, for EphrinA-1 cytoplasmic expression was seen in 184/217 (85 %) of the cases (Table 2, Figure 1).
Gene_expression (expression) of EphA2 associated with cervical cancer
3) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.36 Pain Relevance 0
Human cervical carcinomas that had been shown to express EphA2 and EphrinA-1 have been included in all series as positive controls.
Gene_expression (express) of EphA2 associated with cervical cancer
4) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.37 Pain Relevance 0
High EphA2 expression (strong staining) was significantly correlated to the present of parametrial invasion (P = 0.011).
Gene_expression (expression) of EphA2
5) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.26 Pain Relevance 0
However, EphA2 overexpression has been found to be associated with high cyclin A level, whereas, increase expression of EphrinA-1 correlated with high cyclin A and p21 levels in vulvar cancer 21.
Gene_expression (overexpression) of EphA2 associated with vulvar cancer
6) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.06 Pain Relevance 0
The prognostic significance of EphA2 and EphrinA-1 expression in early stage cervical carcinoma has to our knowledge not been examined.
Gene_expression (expression) of EphA2 associated with cervical cancer
7) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.04 Pain Relevance 0
These studies may indicate that the mechanisms of expression EphA2 and EphrinA-1 are different in various types of cancers.
Gene_expression (expression) of EphA2 associated with cancer
8) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.94 Pain Relevance 0
Furthermore, increase expression of both EphA2 and EphrinA-1 have been observed in vulvar carcinomas 21, cervical carcinomas 22, bladder carcinomas 23, oesophageal carcinomas 24, gastric carcinomas 25 and ovarian carcinomas 26.
Gene_expression (expression) of EphA2 in bladder associated with vulvar cancer, cervical cancer, ovarian cancer, bladder cancer, esophageal cancer and stomach cancer
9) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.13 Pain Relevance 0
In various human cancers poor outcome for the patients has been associated with increase expression of EphA2 and EphrinA-1 16, 17, 19, 24, 26.
Gene_expression (expression) of EphA2 associated with cancer
10) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.09 Pain Relevance 0
The aims of our study were to investigate the expression of EphA2 and EphrinA-1 in a series of 217 early squamous cell cervical carcinomas and to identify predictive markers of the clinical outcome for these patients.


Spec (investigate) Gene_expression (expression) of EphA2 associated with cervical cancer
11) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.02 Pain Relevance 0.05
Contrary, in our previous study of squamous cell cervical carcinomas FIGO stage I-IV we found that increased expression of EphA2 and EphrinA-1 was significantly associated with shorter overall survival in multivariate analysis 22.
Gene_expression (expression) of EphA2 associated with cervical cancer
12) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.91 Pain Relevance 0
There was a clear correlation between expression of EphA2 and EphrinA-1 (P < 0.0001).
Gene_expression (expression) of EphA2
13) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.15 Pain Relevance 0
EphA2 is overexpressed in a variety of human cancers, including breast 12, prostate 13, 14, oesophagus 15, renal 16, lung 17, pancreas 18 and ovarian 19, 20.
Gene_expression (overexpressed) of EphA2 in oesophagus associated with cancer
14) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.02 Pain Relevance 0
In our previous study of cervical carcinomas FIGO stage I-IV we found that increase expression of EphA2 and EphrinA-1 was significantly associated with shorter overall survival in multivariate analysis 22.
Gene_expression (expression) of EphA2 associated with cervical cancer
15) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 1.07 Pain Relevance 0
In normal squamous epithelium weak cytoplasmic staining for EphA2 and EphrinA-1 was present in 4/10 (40%) and 6/10 (60%) of the cases, respectively.
Gene_expression (staining) of EphA2 in squamous epithelium
16) Confidence 0.65 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.42 Pain Relevance 0
Furthermore, high expression (moderate/strong staining) for EphA2 and EphrinA-1 was found in 41% and 43% of the cases, respectively.
Gene_expression (expression) of EphA2
17) Confidence 0.58 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.80 Pain Relevance 0
Expressions of EphA2 and EphrinA-1 in early squamous cell cervical carcinomas and their relation to prognosis

By using immunohistochemistry we investigated the expression of EphA2 and EphrinA-1 in 217 early squamous cell cervical carcinomas and examine their prognostic relevance.

Spec (examine) Gene_expression (Expressions) of EphA2 associated with cervical cancer
18) Confidence 0.58 Published 2008 Journal International Journal of Medical Sciences Section Title Doc Link PMC2424178 Disease Relevance 0.57 Pain Relevance 0
For EphA2 expression, 21 tumors (10%) showed negative, 108 (50%) weak positive, 69 (32%) moderate positive and 19 (9%) strong positive, whereas for EphrinA-1 expression, 33 tumors (15%) showed negative, 91 (42%) weak positive, 67 (31%) moderate positive and 26 (12%) strong positive.
Gene_expression (expression) of EphA2 associated with cancer
19) Confidence 0.58 Published 2008 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2424178 Disease Relevance 0.56 Pain Relevance 0
Previously, a wide range of EphA2 overexpression (34-87%) 15, 17, 19, 22, 24-26 and EphrinA-1 overexpression (41-61%) 22, 24, 26 has been reported in many other human cancer types FIGO stage I-IV, including squamous cell cervical carcinomas were 43% and 46% of the cases overexpressed EphA2 and EphrinA-1, respectively 22.
Gene_expression (overexpressed) of EphA2 associated with cervical cancer and cancer
20) Confidence 0.58 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.77 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox