INT235672

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.44
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gab2) intracellular (Gab2) protein complex (Gab2)
cytoplasm (Gab2)
Anatomy Link Frequency
brain 3
Gab2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 8 89.04 High High
cerebral cortex 4 65.80 Quite High
Morphine 4 15.12 Low Low
ketamine 12 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 24 78.40 Quite High
Hypersensitivity 12 64.72 Quite High
Cancer 160 63.32 Quite High
Glioma 76 62.32 Quite High
Neurological Disease 32 52.96 Quite High
Disease 32 44.12 Quite Low
Infection 8 41.40 Quite Low
Brain Tumor 52 24.72 Low Low
Body Weight 12 6.48 Low Low
Cardiovascular Disorder Under Development 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, inhibition of injected p97-drug conjugates by endogenous material that could competitively occupy receptors at the BBB appears to be minimal.
Negative_regulation (inhibition) of p97
1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.20 Pain Relevance 0
The decrease in p97 concentration in plasma over time is shown in Figure 2b, whereas 10 minutes after injection of iodinated p97, it begins to accumulate in the brain (Figure 2c).
Negative_regulation (decrease) of p97 in brain
2) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.24 Pain Relevance 0.04
Supporting the hypothesis that p97 enters the brain through a receptor-mediated process on the BBB, we have found that the rate of uptake into the brain of i.v. injected 125I-p97 can be inhibited in a dose related manner by an excess of unlabeled p97 (Figure 4), supporting previously published data [52].
Negative_regulation (inhibited) of p97 in brain
3) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.03
Supporting the hypothesis that p97 enters the brain through a receptor-mediated process on the BBB, we have found that the rate of uptake into the brain of i.v. injected 125I-p97 can be inhibited in a dose related manner by an excess of unlabeled p97 [52].
Negative_regulation (inhibited) of p97 in brain
4) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox