INT235675

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Context Info
Confidence 0.84
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.71
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gab2) intracellular (Gab2) protein complex (Gab2)
cytoplasm (Gab2)
Anatomy Link Frequency
body 1
Gab2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 10 61.36 Quite High
ketamine 15 29.36 Quite Low
Spinal cord 5 5.00 Very Low Very Low Very Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Morphine 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
intrathecal 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 200 97.16 Very High Very High Very High
Glioma 95 96.16 Very High Very High Very High
Disease 40 77.96 Quite High
Cardiovascular Disorder Under Development 25 19.76 Low Low
Brain Tumor 65 5.00 Very Low Very Low Very Low
Neurological Disease 40 5.00 Very Low Very Low Very Low
Toxicity 30 5.00 Very Low Very Low Very Low
Body Weight 15 5.00 Very Low Very Low Very Low
Hypersensitivity 15 5.00 Very Low Very Low Very Low
Aging 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stability and Biodistribution of p97
Protein_catabolism (Stability) of p97
1) Confidence 0.84 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.74 Pain Relevance 0.03
The stability of p97-PTAX conjugate was verified in buffer and in serum samples at ambient (room) temperature, taken at different time points after injection by SDS-PAGE analysis and HPLC analysis.
Protein_catabolism (stability) of p97-PTAX
2) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
The stability of the p97-ADR conjugates was directly assessed by analyzing tissues and body fluids post injection. p97-[14C]ADR conjugate was stable in mouse serum for at least 1 h, with some degradation observed after 18 h (Figure 6a).
Protein_catabolism (stability) of p97 in body
3) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
To determine the stability of the p97-ADR conjugate, SYN002 was prepared with [14C]-labeled ADR.
Spec (determine) Protein_catabolism (stability) of p97
4) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.25 Pain Relevance 0
The stability of iodinated p97 was verified at room temperature in buffer and in serum samples taken at different time points after injection.
Protein_catabolism (stability) of p97
5) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.72 Pain Relevance 0.03

General Comments

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