INT235676

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.12
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gab2) intracellular (Gab2) protein complex (Gab2)
cytoplasm (Gab2)
Anatomy Link Frequency
brain 1
parenchyma 1
Gab2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 6 95.88 Very High Very High Very High
Morphine 6 45.20 Quite Low
Central nervous system 12 11.72 Low Low
ketamine 18 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
intrathecal 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurological Disease 48 97.96 Very High Very High Very High
Hypersensitivity 18 96.72 Very High Very High Very High
Toxicity 36 96.40 Very High Very High Very High
Disease 48 92.24 High High
Body Weight 18 36.56 Quite Low
Brain Tumor 78 25.64 Quite Low
Infection 12 25.64 Quite Low
Cancer 240 5.00 Very Low Very Low Very Low
Glioma 114 5.00 Very Low Very Low Very Low
Cardiovascular Disorder Under Development 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the transport of p97 and p97-conjugates does not appear to be adversely affected by the antiport activities of pumps such as Pgp-1.
Localization (transport) of p97
1) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.26 Pain Relevance 0
Furthermore, p97-PTAX was clearly identified in brain parenchyma (Figure 5f), whereas free PTAX could not be seen in brain but was visualized in other organs such as heart and liver (not shown).
Localization (visualized) of p97-PTAX in brain
2) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
Finally, the transport of p97 and p97-conjugates does not appear to be adversely affected by the antiport activities of pumps such as Pgp-1.
Localization (transport) of p97
3) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.26 Pain Relevance 0
Here we have focused on the iron binding protein p97 (melanotransferrin), a protein closely related to Tf and lactoferrin (Lf) [42].
Localization (related) of p97
4) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.35 Pain Relevance 0
Thirdly, exogenously-introduced p97 can be expected to localize in concert with the tissue distribution of the target receptor.
Localization (localize) of p97
5) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.25 Pain Relevance 0
As the BBB isolates the cortex from all systemic influences, any systemically i.v. administered 125I-p97 recovered from the brain parenchyma must have penetrated the BBB from the circulation.
Localization (recovered) of p97 in parenchyma
6) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.05

General Comments

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