INT235680

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 4.93
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gab2) intracellular (Gab2) protein complex (Gab2)
cytoplasm (Gab2)
Anatomy Link Frequency
brain 7
eye 1
lung 1
heart 1
parenchyma 1
Gab2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 36 95.68 Very High Very High Very High
Morphine 18 85.84 High High
ketamine 54 75.04 Quite High
cerebral cortex 18 36.96 Quite Low
Spinal cord 18 5.00 Very Low Very Low Very Low
methotrexate 18 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Neurotransmitter 18 5.00 Very Low Very Low Very Low
alcohol 18 5.00 Very Low Very Low Very Low
intrathecal 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 342 98.88 Very High Very High Very High
Cancer 720 98.60 Very High Very High Very High
Brain Tumor 234 96.76 Very High Very High Very High
Sarcoma 36 90.76 High High
Body Weight 54 77.20 Quite High
Sprains And Strains 18 77.12 Quite High
Toxicity 108 74.08 Quite High
Leukemia 18 64.32 Quite High
Lymphatic System Cancer 18 62.64 Quite High
Solid Tumor 18 61.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also suggests that the brain expresses a higher concentration of receptors for p97 than these other organs.
Gene_expression (expresses) of p97 in brain
1) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
Accumulation of homologous (murine) p97 would possibly be even greater than of the heterologous (human) p97 studied here and perhaps bodes well for transfer of this technology into a clinical application in humans.
Gene_expression (transfer) of p97
2) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.08 Pain Relevance 0.11
Specific staining for p97-DIG was observed in the brain parenchyma abluminal to the microvasculature.
Gene_expression (staining) of p97-DIG in parenchyma
3) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
Despite weak fixation, the BBB was demonstrated to be intact, indicating that p97-DIG crossed into the brain without disruption of the BBB.
Neg (without) Gene_expression (crossed) of p97-DIG in brain
4) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
In Trial 1, we showed that p97-ADR (SYN002) was as effective in inhibiting subcutaneous glioma tumor growth as an equivalent amount of free ADR (over 50% reduction in tumor mass over a period of 19 days) (Figure 7a).
Gene_expression (effective) of p97 associated with cancer and glioma
5) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.58 Pain Relevance 0
The addition of unlabeled p97 did not change the entry rate for 99Tc-albumin (overall Ki?
Gene_expression (addition) of p97
6) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
Furthermore, p97-PTAX was clearly identified in brain parenchyma (Figure 5f), whereas free PTAX could not be seen in brain but was visualized in other organs such as heart and liver (not shown).
Gene_expression (identified) of p97-PTAX in brain
7) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
One hour after injection, 125I-p97 levels in the blood, kidney, bladder, liver, spleen, gallbladder, eye, heart and lung were all higher than in the central nervous system (Figure 2a).
Gene_expression (levels) of p97 in eye associated with central nervous system
8) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.53 Pain Relevance 0.05
In Trial 5 (Table 2 and Figure 6b), we showed that similar amounts of p97 as p97-ADR conjugates (SYN019 and SYN020) were transported into the brains of mice after tail vein injection.
Gene_expression (amounts) of p97 in brains
9) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.58 Pain Relevance 0
We find that while p97-PTAX conjugates effectively cross the BBB, we chose to study the therapeutic effects of ADR because PTAX lacks tumorcidal or cytostatic activity against C6 gliomas [68].
Gene_expression (cross) of p97-PTAX associated with glioma
10) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.90 Pain Relevance 0
In Trial 5 (Table 2 and Figure 6b), we showed that similar amounts of p97 as p97-ADR conjugates (SYN019 and SYN020) were transported into the brains of mice after tail vein injection.
Gene_expression (amounts) of p97 in brains
11) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.58 Pain Relevance 0
The MSR for the p97-ADR conjugates ranged between 5 and 6.
Gene_expression (conjugates) of p97
12) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.18 Pain Relevance 0
We have also shown that PTAX-conjugated-p97 is transported to the brain (Figure 5f), whereas free PTAX could not be detected.
Gene_expression (transported) of p97 in brain
13) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.21 Pain Relevance 0
Stability and Quality of p97-ADR Conjugates
Gene_expression (Stability) of p97
14) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.23 Pain Relevance 0
Synthesis and Analysis of p97-ADR Conjugates
Gene_expression (Synthesis) of p97
15) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.04
The p97-PTAX conjugate (Figure 5f) and its metabolites were detected in brain tissue but free PTAX was not detected in the brain (Table 1).
Gene_expression (detected) of p97-PTAX in brain
16) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
One hour after injection, 125I-p97 levels in the blood, kidney, bladder, liver, spleen, gallbladder, eye, heart and lung were all higher than in the central nervous system (Figure 2a).
Gene_expression (levels) of p97 in heart associated with central nervous system
17) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.53 Pain Relevance 0.05
One hour after injection, 125I-p97 levels in the blood, kidney, bladder, liver, spleen, gallbladder, eye, heart and lung were all higher than in the central nervous system (Figure 2a).
Gene_expression (levels) of p97 in lung associated with central nervous system
18) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.53 Pain Relevance 0.05

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