INT235682

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 2.37
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gab2) intracellular (Gab2) protein complex (Gab2)
cytoplasm (Gab2)
Anatomy Link Frequency
brain 5
vasculature 1
Gab2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 9 89.80 High High
Central nervous system 18 80.72 Quite High
Inflammation 9 39.28 Quite Low
Morphine 9 39.12 Quite Low
intrathecal 9 17.12 Low Low
Spinal cord 9 12.88 Low Low
ketamine 27 5.00 Very Low Very Low Very Low
methotrexate 9 5.00 Very Low Very Low Very Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 360 98.72 Very High Very High Very High
Neurological Disease 72 98.60 Very High Very High Very High
Body Weight 27 96.28 Very High Very High Very High
Disease 72 92.88 High High
Cardiovascular Disorder Under Development 45 91.20 High High
Toxicity 54 83.80 Quite High
Brain Tumor 117 81.04 Quite High
Hypersensitivity 27 73.72 Quite High
Glioma 171 56.32 Quite High
Lysosomal Storage Diseases 18 46.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that 125I-p97 does not associate with the CNS vasculature but is transcytosed through the endothelial cells into the brain parenchyma, consistent with past findings [10], [44], [74].
p97 Binding (associate) of in vasculature
1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.04
Six hours after i.v. injection into mice, we found most 125I-p97 (over 80%) associated with the brain parenchyma rather than in the brain capillaries.
p97 Binding (associated) of in brain
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.04
Nevertheless, these studies demonstrate that p97, once conjugated to drug compounds, can cross the blood brain barrier at a similar rate to its normal (unconjugated) physiological efficiency and that the molecule remains intact following transcytosis but its payload is fully tumoricidally active once placed inside the brain and behind the BBB.
p97 Binding (conjugated) of in brain
3) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.32 Pain Relevance 0
We have also shown that PTAX-conjugated-p97 is transported to the brain (Figure 5f), whereas free PTAX could not be detected.
p97 Binding (conjugated) of in brain
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.20 Pain Relevance 0
Here we have focused on the iron binding protein p97 (melanotransferrin), a protein closely related to Tf and lactoferrin (Lf) [42].
p97 Binding (binding) of
5) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.35 Pain Relevance 0
Efficacy of p97-ADR Conjugates on Intracranial Tumors
p97 Binding (Efficacy) of associated with cancer
6) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.57 Pain Relevance 0
Nevertheless, these studies demonstrate that p97, once conjugated to drug compounds, can cross the blood brain barrier at a similar rate to its normal (unconjugated) physiological efficiency and that the molecule remains intact following transcytosis but its payload is fully tumoricidally active once placed inside the brain and behind the BBB.
p97 Binding (cross) of in brain
7) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.32 Pain Relevance 0
In contrast, when p97-ADR was administered, the levels of both markers were similar to that seen after PBS injections, indicating that conjugation to p97 could reduce the toxic effects of ADR in future clinical settings.
p97 Binding (conjugation) of
8) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.44 Pain Relevance 0
After 6 h, the majority of 125I-p97 associated with the brain was localized to the brain parenchyma (83%), and not the blood vessels (Figure 3).
p97 Binding (associated) of in brain
9) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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