INT235683

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.49
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Clcn1) transmembrane transport (Clcn1)
Anatomy Link Frequency
muscle 1
Clcn1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 10 56.56 Quite High
imagery 10 5.00 Very Low Very Low Very Low
gABA 9 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 35 100.00 Very High Very High Very High
Hypopituitarism 13 98.76 Very High Very High Very High
Cataract 4 98.56 Very High Very High Very High
Body Weight 4 97.52 Very High Very High Very High
Movement Disorders 2 91.20 High High
Cancer 41 85.44 High High
Targeted Disruption 28 83.32 Quite High
Cardiovascular Disorder Under Development 5 80.32 Quite High
Frailty 24 70.76 Quite High
Glioma 19 60.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to the dysregulation of other genes in DM1 (CLCN-1, IR) [5], the expression of CUGexp but not CAGexp transcripts [37] triggers a shift in the ratios of alternatively spliced GABT4 transcripts that resembles those found during fetal development.
Regulation (dysregulation) of CLCN-1
1) Confidence 0.21 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.25 Pain Relevance 0.03
Consistent with the involvement of MBNL proteins in the RNA gain of function mechanism, Mbnl1 knockdown mice [60] showed DM1-like phenotypes including iridescent cataracts, myotonia and missplicing of muscle transcripts that had been reported altered in DM1 patients such as IR and CLC-1 pre-mRNA [61, 62]. muscleblind mutant embryos similarly showed altered expression of muscle transcript isoforms from the Drosophila ZASP homologue and alpha-actinin genes [63].
Regulation (altered) of CLC-1 in muscle associated with hypopituitarism and cataract
2) Confidence 0.17 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.39 Pain Relevance 0
Treatment with an equivalent amount of ADR conjugated to p97 (SYN002) had little effect on the level of these markers of cardiac cell damage, implying that conjugating ADR to p97 may reduce the cardiotoxic effects of ADR treatment.
Regulation (effects) of ADR
3) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.52 Pain Relevance 0
In this respect, measuring the proportion of patients who respond favorably to treatment without being affected by adverse drug reactions (ADR) could be a suitable endpoint.
Neg (without) Regulation (affected) of ADR associated with adverse drug reaction
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2570485 Disease Relevance 0.34 Pain Relevance 0

General Comments

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