INT235686

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Top2a) nucleoplasm (Top2a) chromosome segregation (Top2a)
enzyme binding (Top2a) DNA binding (Top2a) protein complex (Top2a)
Anatomy Link Frequency
skin 1
cervix 1
Top2a (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 27.56 Quite Low
cytokine 6 20.40 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 99.58 Very High Very High Very High
Epstein-barr Virus 3 99.12 Very High Very High Very High
Hodgkin's Disease 22 98.48 Very High Very High Very High
Stress 2 98.28 Very High Very High Very High
Multiple Myeloma 1 93.68 High High
Sarcoma 2 92.96 High High
Skin Cancer 10 91.36 High High
Cervical Cancer 18 90.08 High High
Cancer 114 89.72 High High
Solid Tumor 1 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We did not observe significant modulation of TOP2A gene expression in cervix from K14E6 mice.
Gene_expression (expression) of TOP2A gene in cervix
1) Confidence 0.60 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 1.19 Pain Relevance 0
In our study, TOP2A gene was found differentially expressed in skin from K14E6 as compared to nontrangenic mice.
Gene_expression (expressed) of TOP2A gene in skin
2) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.98 Pain Relevance 0
Reduction of oxidative stress due to complexes of metal ions and anthracyclines by chelating metal ionsBlockade of topoisomerase II poisons by catalytic inhibition of topoisomerase II
Gene_expression (poisons) of topoisomerase II associated with stress
3) Confidence 0.34 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697522 Disease Relevance 0.17 Pain Relevance 0
Wang et al. evaluated the association of p53 with the clinical stage, EBV, bcl-2, retinoblastoma gene, p21, Ki67 and topoisomerase-II-alfa and detected p53 gene in 14 patients among the 62 CHL cases.
Gene_expression (detected) of topoisomerase-II associated with hodgkin's disease, epstein-barr virus and retinoblastoma
4) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.84 Pain Relevance 0
ADR inhibits the progression of the enzyme topoisomerase II after it has broken the DNA chain to allow replication; it prevents the DNA double helix from being religated [86], [87].
Gene_expression (progression) of topoisomerase II
5) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 1.16 Pain Relevance 0

General Comments

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