INT235687

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 1.52
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gab2) intracellular (Gab2) protein complex (Gab2)
cytoplasm (Gab2)
Anatomy Link Frequency
brain 7
Gab2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 97.12 Very High Very High Very High
Central nervous system 20 94.88 High High
cerebral cortex 10 22.96 Low Low
ketamine 30 21.24 Low Low
Spinal cord 10 5.00 Very Low Very Low Very Low
methotrexate 10 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
intrathecal 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 30 96.64 Very High Very High Very High
Cardiovascular Disorder Under Development 50 91.20 High High
Toxicity 60 82.80 Quite High
Neurological Disease 80 71.72 Quite High
Cancer 400 67.00 Quite High
Glioma 190 66.00 Quite High
Brain Tumor 130 48.88 Quite Low
Disease 80 47.80 Quite Low
Hypersensitivity 30 5.00 Very Low Very Low Very Low
Aging 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike the other organs, the brain continued to accumulate p97 at 24 hours after injection.
Positive_regulation (accumulate) of p97 in brain
1) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.04
After 24 hrs, the total accumulation of p97 in the brain reached 1–2% of the injected dose.


Positive_regulation (accumulation) of p97 in brain
2) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.04
In contrast, when p97-ADR was administered, the levels of both markers were similar to that seen after PBS injections, indicating that conjugation to p97 could reduce the toxic effects of ADR in future clinical settings.
Positive_regulation (conjugation) of p97
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.44 Pain Relevance 0
The two conjugates were found to have 4 to 7 molecules of ADR per molecule of p97 at an ADR concentration of 17 to 60.6 µg/ml.


Positive_regulation (molecules) of p97
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
The organ distribution of 125I-p97, its brain accumulation over time and the fact that the BBB microvasculature lacks albumin receptors suggests that 125I-p97 entry into the brain is likely due to a receptor.
Positive_regulation (accumulation) of p97 in brain
5) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.09 Pain Relevance 0.13
However, after 1 hr, p97 was found to accumulate in the brain while its uptake in all other organs fell to the same level as the albumin control.
Positive_regulation (accumulate) of p97 in brain
6) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.26 Pain Relevance 0.05
Unlike the other organs, the brain continued to accumulate p97, even 24 hours post injection.
Positive_regulation (accumulate) of p97 in brain
7) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.25 Pain Relevance 0.10
After 24 hr, the total accumulation of p97 in the brain reached 1–2% of the injected dose equivalent to the ratio of brain to body weight-the first carrier system to approximate this biological feat.
Positive_regulation (accumulation) of p97 in brain associated with body weight
8) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.15 Pain Relevance 0.12
After 1 hr, p97 was found to accumulate in the brain while its level in all other organs decreased.
Positive_regulation (accumulate) of p97 in brain
9) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.26 Pain Relevance 0.05
Accumulation of homologous (murine) p97 would possibly be even greater than of the heterologous (human) p97 studied here and perhaps bodes well for transfer of this technology into a clinical application in humans.
Positive_regulation (Accumulation) of p97
10) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.08 Pain Relevance 0.12

General Comments

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