INT235692

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Clcn1) cytoskeleton (Alms1) cilium (Alms1)
molecular_function (Alms1) lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
brain 2
Clcn1 (Mus musculus)
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
intrathecal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Tumor 13 100.00 Very High Very High Very High
Cancer 40 81.80 Quite High
Glioma 19 76.12 Quite High
Multiple Myeloma 1 61.16 Quite High
Sarcoma 2 60.44 Quite High
Solid Tumor 1 56.56 Quite High
Lymphatic System Cancer 1 55.60 Quite High
Leukemia 1 54.80 Quite High
Sprains And Strains 1 48.28 Quite Low
Toxicity 6 18.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in the chemotherapeutic trials conducted here, ADR conjugates were particularly good candidates for evaluation because free ADR is excluded from the brain by Pgp1 efflux activity and because ADR is completely ineffective in treating brain tumors [92] because of hindrance by the BBB.
ADR Positive_regulation (ineffective) of BBB Binding (hindrance) of in brain associated with brain tumor
1) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.90 Pain Relevance 0

General Comments

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