INT235693

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Clcn1) plasma membrane (Gab2) intracellular (Gab2)
protein complex (Gab2) cytoplasm (Gab2) transmembrane transport (Clcn1)
Anatomy Link Frequency
brain 2
body 1
Clcn1 (Mus musculus)
Gab2 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 21 44.68 Quite Low
Central nervous system 14 28.88 Quite Low
Spinal cord 7 5.00 Very Low Very Low Very Low
cerebral cortex 7 5.00 Very Low Very Low Very Low
methotrexate 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Morphine 7 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
intrathecal 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 133 98.92 Very High Very High Very High
Cancer 280 96.88 Very High Very High Very High
Disease 56 93.28 High High
Cardiovascular Disorder Under Development 35 87.00 High High
Body Weight 21 84.72 Quite High
Brain Tumor 91 76.52 Quite High
Toxicity 42 67.52 Quite High
Multiple Myeloma 7 35.52 Quite Low
Sarcoma 14 34.80 Quite Low
Solid Tumor 7 30.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that conjugation of ADR to p97 does not affect the transport of p97 into the brain.


ADR Binding (conjugation) of p97 in brain
1) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.31 Pain Relevance 0
We chose to examine the therapeutic effects of ADR and p97-ADR conjugates rather than PTAX and p97-PTAX because C6 is resistant to the cytostatic activity of PTAX [68].
ADR Binding (conjugates) of p97-PTAX
2) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.77 Pain Relevance 0
Treatment with an equivalent amount of ADR conjugated to p97 (SYN002) had little effect on the level of these markers of cardiac cell damage, implying that conjugating ADR to p97 may reduce the cardiotoxic effects of ADR treatment.
ADR Binding (conjugated) of p97
3) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.51 Pain Relevance 0
The stability of the p97-ADR conjugates was directly assessed by analyzing tissues and body fluids post injection. p97-[14C]ADR conjugate was stable in mouse serum for at least 1 h, with some degradation observed after 18 h (Figure 6a).
ADR Binding (conjugate) of p97 in body
4) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0
Treatment of C6 gliomas grown subcutaneously in mice was performed with both p97-ADR conjugate (SYN002) and free ADR.
ADR Binding (conjugate) of p97 associated with glioma
5) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.36 Pain Relevance 0
Treatment of C6 gliomas grown subcutaneously in mice was performed with both p97-ADR conjugate (SYN002) and free ADR.
ADR Binding (conjugate) of p97 associated with glioma
6) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.36 Pain Relevance 0
The data further demonstrated that therapeutic amounts of ADR [30], could be delivered into the brain upon conjugation to p97.
ADR Binding (conjugation) of p97 in brain
7) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.65 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox