INT235725

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.71
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
Anatomy Link Frequency
platelet 1
fibroblast 1
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 1 100.00 Very High Very High Very High
peripheral neuropathy 1 98.60 Very High Very High Very High
cytokine 8 94.80 High High
antagonist 8 49.92 Quite Low
metalloproteinase 2 36.12 Quite Low
Pain 15 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 5 99.90 Very High Very High Very High
Ulcers 1 99.70 Very High Very High Very High
Ovarian Cancer 102 99.44 Very High Very High Very High
Peripheral Neuropathy 1 98.60 Very High Very High Very High
Cancer 161 98.44 Very High Very High Very High
Stomach Cancer 4 98.26 Very High Very High Very High
Adhesions 12 97.84 Very High Very High Very High
Fatigue 11 97.56 Very High Very High Very High
Neutropenia 7 97.16 Very High Very High Very High
Breast Cancer 4 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the lowest arrow exhibits a protein that has no dependence on c-Src activation, as its RGD-stimulated phosphorylation in the presence of DNSrc is unchanged from control cells.
Neg (no) Regulation (dependence) of c-Src associated with addiction
1) Confidence 0.44 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.05
These include drugs targeted against the epidermal growth factor, platelet-derived growth factor, vascular endothelial growth factor, src kinase, histone deacetylase, the proteasome, and mesothelin.
Regulation (targeted) of src in platelet
2) Confidence 0.27 Published 2008 Journal Curr Treat Options Oncol Section Abstract Doc Link PMC2782121 Disease Relevance 0.28 Pain Relevance 0
Src kinases are controlled by tyrosine kinase receptors (EGFR, PDGFR, fibroblast growth factor receptors), integrin receptors, G-protein coupled receptors, cytokine receptors, and steroid hormone receptors (Thomas and Brugge 1997).
Regulation (controlled) of Src in fibroblast associated with cytokine
3) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.82 Pain Relevance 0.05
In gastric cancer cell lines, induction of CIP2A expression following Helicobacter pylori infection was dependent on Src and Ras/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways [9].
Regulation (dependent) of Src associated with ulcers, infection and stomach cancer
4) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2984408 Disease Relevance 1.24 Pain Relevance 0
The Src-family kinases are the largest family of nonreceptor protein tyrosine kinases and are responsible for signal transduction during many cellular activities, including differentiation, adhesion, and migration.
Regulation (responsible) of Src associated with adhesions
5) Confidence 0.09 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 1.15 Pain Relevance 0.05
Src is thus emerging as a new target for antiangiogenic treatment of ovarian cancer.
Regulation (target) of Src associated with ovarian cancer
6) Confidence 0.06 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.23 Pain Relevance 0.04
Throughout 2004, two independent observers who did not participate in the surgery (ASV and JFL) reviewed the medical histories and radiographies of each patient, categorizing the radiographs into those that were possibly, probably or definitely loose.
Neg (not) Regulation (participate) of ASV
7) Confidence 0.05 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2426685 Disease Relevance 0 Pain Relevance 0

General Comments

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