INT235742

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Smad4) nucleolus (Smad4) nucleus (Smad4)
intracellular (Smad4) protein binding transcription factor activity (Smad4) DNA binding (Smad4)
Smad4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 20 73.28 Quite High
Spinal cord 1 52.72 Quite High
Central nervous system 7 49.76 Quite Low
Hippocampus 22 37.92 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 51 99.72 Very High Very High Very High
Disease 33 96.80 Very High Very High Very High
Infection 60 95.12 Very High Very High Very High
Necrosis 6 88.20 High High
Cancer 5 87.84 High High
Death 55 79.20 Quite High
INFLAMMATION 28 73.28 Quite High
Injury 35 72.64 Quite High
Stress 3 64.80 Quite High
Optic Nerve Injuries 34 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pro-apoptotic genes, associated to the intrinsic apoptotic pathway, are regulated after IONT and IONC (14–3–3, RAD9, RASSF4, Rb protein, Smad4, PPM1B), although IONT (BMF, Bcl.10, Bax, Bcl-B, DLC1, MCL1) seems to trigger a higher response than IONC does.
Spec (seems) Regulation (regulated) of Smad4 associated with apoptosis
1) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.29 Pain Relevance 0.06
Receptor 1 as well as those coding for the receptor regulated R-Smads 2 and 3 and the Co Smad 4 were found to be up-regulated.
Regulation (regulated) of Co Smad 4
2) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.38 Pain Relevance 0

General Comments

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