INT235746

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.67
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp2) mitochondrion (Casp2) aging (Casp2)
nucleus (Casp2) intracellular (Casp2) molecular_function (Casp2)
Anatomy Link Frequency
optic nerve 1
Casp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 216 100.00 Very High Very High Very High
Central nervous system 1 90.08 High High
Spinal cord 1 88.16 High High
Inflammation 7 34.56 Quite Low
Inflammatory response 4 27.36 Quite Low
Hippocampus 4 21.92 Low Low
cerebral cortex 4 21.28 Low Low
isoflurane 8 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 216 100.00 Very High Very High Very High
Death 55 99.08 Very High Very High Very High
Optic Nerve Injuries 34 97.40 Very High Very High Very High
Injury 60 95.60 Very High Very High Very High
Apoptosis 31 93.64 High High
Retina Disease 4 91.60 High High
Stress 10 82.56 Quite High
Cv Unclassified Under Development 6 81.04 Quite High
Middle Cerebral Artery Infarction 4 72.40 Quite High
Necrosis 5 49.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of caspase 2 are important in cell death activated by DNA damage [50], and we found this gene to be downregulated by both injuries, which suggests that DNA damage is not the main pathway for the optic nerve injury-induced retinal degeneration.
Positive_regulation (Increased) of caspase 2 in optic nerve associated with optic nerve injuries, injury, retina disease and death
1) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.19 Pain Relevance 0.09
Therefore, as an example, we demonstrate the impact of different reference gene selection methods on determining the transcript levels of transient receptor potential melastatin 2 (TRPM2) channels following ICH.
Positive_regulation (following) of ICH associated with cva
2) Confidence 0.02 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2823748 Disease Relevance 0.62 Pain Relevance 0.15
We also compared the stability of the candidate reference genes at individual time points following collagenase-induced ICH (5 and 24 hours).
Positive_regulation (induced) of ICH associated with cva
3) Confidence 0.02 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2823748 Disease Relevance 0.29 Pain Relevance 0.14
We quantified the transcript level of seven candidate reference genes (B2MG, GUSB, GAPDH, HPRT, POL2R, SDHA and TBP) and our gene of interest, TRPM2, in the perihematomal and matching contralateral regions in rats 5 and 24 hours following collagenase-induced ICH, as well as in saline vehicle controls.
Positive_regulation (induced) of ICH associated with cva
4) Confidence 0.02 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2823748 Disease Relevance 0.19 Pain Relevance 0.09
Figure 2 shows geNorm output charts from the combined group of all collagenase-induced ICH and saline vehicle rats.
Positive_regulation (induced) of ICH associated with cva
5) Confidence 0.02 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2823748 Disease Relevance 0.38 Pain Relevance 0.19

General Comments

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