INT235753

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 5.41
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Tradd) cytoplasm (Tradd)
Anatomy Link Frequency
brain 1
Tradd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 81 99.56 Very High Very High Very High
ischemia 256 87.68 High High
Intracerebroventricular 27 5.52 Low Low
Inflammation 33 5.00 Very Low Very Low Very Low
cerebral cortex 27 5.00 Very Low Very Low Very Low
medulla 27 5.00 Very Low Very Low Very Low
cva 27 5.00 Very Low Very Low Very Low
alcohol 18 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
Hippocampus 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 31 99.28 Very High Very High Very High
Targeted Disruption 387 99.08 Very High Very High Very High
Injury 190 98.60 Very High Very High Very High
Optic Nerve Injuries 68 93.72 High High
Neurodegenerative Disease 9 92.80 High High
Apoptosis 233 91.04 High High
Death 228 89.84 High High
Brain Hemorrhage 153 88.88 High High
Infarction 36 82.56 Quite High
Brain Injury 9 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naïve and injured RGCs expressed TRADD and c-fos as seen by colocalization of the fluorogold tracer and red fluorescence immunoreactivity.
Gene_expression (expressed) of TRADD
1) Confidence 0.62 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 0.86 Pain Relevance 0
There were no significant differences between TRADD protein expression in the normally-perfused hemisphere and the ischemic border zone or infarct core in the TNF?
Gene_expression (expression) of TRADD protein
2) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.85 Pain Relevance 0.08
protein synthesized in the brain of the transgenic animal is biologically active, we quantified expression of TRADD protein.
Gene_expression (expression) of TRADD protein in brain associated with targeted disruption
3) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.32 Pain Relevance 0.04
enhanced expression of TRADD protein without ischemic stress, we sampled cortical tissue from the normally-perfused hemisphere in ischemic animals and found that TRADD was nearly threefold higher in the TNF?
Gene_expression (expression) of TRADD protein associated with stress
4) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.54 Pain Relevance 0.07
The levels of TRADD protein also increased after both injuries in our study.
Gene_expression (levels) of TRADD associated with injury
5) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.04 Pain Relevance 0
enhanced expression of TRADD protein without ischemic stress, we sampled cortical tissue from the normally-perfused hemisphere in ischemic animals and found that TRADD was nearly threefold higher in the TNF?
Gene_expression (higher) of TRADD associated with stress
6) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.64 Pain Relevance 0.07
Regional expression of TRADD protein was uniformly higher in TNF?
Gene_expression (expression) of TRADD protein
7) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.29 Pain Relevance 0.05
After 3 hours of post-ischemic reperfusion, mean TRADD expression in TNF?
Gene_expression (expression) of TRADD
8) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.28 Pain Relevance 0.05
We measured expression of TRADD protein, derived upon interaction of active, soluble TNF?
Gene_expression (expression) of TRADD protein
9) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0 Pain Relevance 0
The expression of TRADD protein was determined by western blot analysis using a monoclonal anti-TRADD antibody (BD Biosciences, USA).
Gene_expression (expression) of TRADD protein
10) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0 Pain Relevance 0
Our observation that TRADD protein is expressed intensely within and outside of the ischemic focus in TNF?
Gene_expression (expressed) of TRADD protein
11) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.59 Pain Relevance 0.12

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