INT235754

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.47
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Casp4)
Casp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 76 92.08 High High
Inflammation 3 89.84 High High
cytokine 2 78.76 Quite High
isoflurane 2 56.00 Quite High
potassium channel 2 31.56 Quite Low
Spinal cord 1 19.12 Low Low
Central nervous system 1 16.16 Low Low
anesthesia 9 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 69 100.00 Very High Very High Very High
Metabolic Disorder 2 99.04 Very High Very High Very High
Cancer 5 98.36 Very High Very High Very High
Necrosis 5 98.12 Very High Very High Very High
Reperfusion Injury 28 92.84 High High
Death 59 92.68 High High
Cv Unclassified Under Development 76 92.08 High High
INFLAMMATION 7 89.84 High High
Stress 6 81.36 Quite High
Optic Nerve Injuries 34 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results show that the Casp4 gene, a gene involved in apoptosis, has increased while the Timp1 gene and Casp8 genes have decreased.
Positive_regulation (increased) of Casp4 gene associated with apoptosis
1) Confidence 0.42 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 0.84 Pain Relevance 0.10
In addition, the Bard1 and Casp4 genes are significantly increased, while the Casp8 and Timp1 genes are significantly decreased compared to the
Positive_regulation (increased) of Casp4
2) Confidence 0.42 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 0.22 Pain Relevance 0.08
This is strengthened by the upregulation after IONT and IONC of caspases 3 and 11 (caspase 4 in humans) and of another member of the tumor necrosis factor family, TNRSF12A (Fn14), which is also linked to apoptosis through TRADD signaling [29,30,45].
Positive_regulation (upregulation) of caspase 4 associated with necrosis, cancer and apoptosis
3) Confidence 0.08 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.40 Pain Relevance 0.04

General Comments

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