INT23577

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Context Info
Confidence 0.73
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 5.32
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
GL1 1
B cells 1
brain 1
T lymphocytes 1
IgG-2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 40 99.54 Very High Very High Very High
Catecholamine 1 96.44 Very High Very High Very High
Neuritis 21 95.76 Very High Very High Very High
Morphine 6 91.36 High High
Inflammation 48 88.96 High High
Neuropeptide 1 88.68 High High
Demyelination 3 87.16 High High
Arthritis 61 85.12 High High
cytokine 43 76.80 Quite High
Crohn's disease 36 50.88 Quite High
Disease Link Frequency Relevance Heat
Disease 84 99.42 Very High Very High Very High
Experimental Autoimmune Neuritis 21 95.76 Very High Very High Very High
Sprains And Strains 23 94.60 High High
Immunization 13 93.20 High High
Syndrome 3 90.28 High High
INFLAMMATION 48 88.96 High High
Demyelinating Disease 3 87.16 High High
Inflammatory Bowel Disease 78 85.80 High High
Arthritis 75 85.12 High High
Abscess 1 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, phycoerythrin (PE) conjugated; BD Biosciences] and CD86 (GL1, rat IgG2a ?
Localization (rat) of IgG2a in GL1
1) Confidence 0.73 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.15
, PE conjugated; BD Biosciences); and chemokine receptors CCR7 (4B12, rat IgG2a ?
Localization (rat) of IgG2a associated with chemokine
2) Confidence 0.73 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.15
200, clone RA3-6B2, rat IgG2a, BD Biosciences,), anti-rat CD45R (1?
Localization (rat) of IgG2a
3) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440803 Disease Relevance 0 Pain Relevance 0
In late disease (6 to 8 weeks after onset), titres of both IgG1 and IgG2a/c had increased modestly in DBA/1 mice.
Localization (titres) of IgG2a associated with disease
4) Confidence 0.73 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 1.60 Pain Relevance 0.32
Primary antibodies included (1) anti-CD3 (monoclonal mouse IgG2a, Biocarta, Hamburg, Germany) to mark mucosal T lymphocytes, (2) anti-IgA antibody (?
Localization (monoclonal) of IgG2a in T lymphocytes
5) Confidence 0.73 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 0.45 Pain Relevance 0.14
We examined whether autoradiographic localization of [125I]-antirabbit immunoglobulin (IgG) was suitable for light and electron microscopic detection of a rabbit antiserum to the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), and whether autoradiographic and peroxidase labeling could be combined for simultaneous immunocytochemical identification of TH and neuropeptides in brain.
Spec (whether) Localization (localization) of IgG in brain associated with catecholamine and neuropeptide
6) Confidence 0.05 Published 1986 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2422251 Disease Relevance 0 Pain Relevance 0.09
The numbers of cells secreting IgG antibodies to BPM, P2, P0, GM1 and MAG peptides were also elevated before disease onset, but they were mostly higher than those of IgM antibodies and they reached their maximum only after recovery.
Localization (ecreting ) of IgG associated with disease
7) Confidence 0.01 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7528788 Disease Relevance 1.09 Pain Relevance 0.59
Maximum numbers of IgG antibodies secreting cells were generally reached at the height of clinical disease.
Localization (ecreting ) of IgG associated with disease
8) Confidence 0.01 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7528788 Disease Relevance 1.11 Pain Relevance 0.61
One pathway requires interferon-gamma to stimulate IgM-secreting cells to switch to IgG2a-secreting cells.
Localization (secreting) of IgG2a
9) Confidence 0.01 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8768720 Disease Relevance 0 Pain Relevance 0.44
Lewis rats were immunized with bovine peripheral nerve myelin (BPM), and levels of B cells secreting IgM and IgG antibodies to BPM, P2 and P0, the glycolipid GM1 and five peptides of myelin-associated glycoprotein (MAG) were determined.
Localization (ecreting ) of IgG in B cells
10) Confidence 0.00 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7528788 Disease Relevance 1.07 Pain Relevance 0.60

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