INT235783

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.59
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAX6) nucleolus (PAX6) nucleus (PAX6)
DNA binding (PAX6) transcription factor binding (PAX6) cytoplasm (PAX6)
Anatomy Link Frequency
eye 2
retina 2
corneal epithelium 2
PAX6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 5 54.24 Quite High
antagonist 6 27.88 Quite Low
imagery 28 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 60 99.76 Very High Very High Very High
Disease 14 95.68 Very High Very High Very High
Syndrome 15 94.32 High High
Conjunctiva Disease 5 93.68 High High
Eye Malformation 7 76.56 Quite High
Adhesions 5 74.04 Quite High
Obesity 11 72.56 Quite High
Aniridia 84 65.92 Quite High
Hyperglycemia 2 64.60 Quite High
Ocular Toxicity (including Many Sub-types) 8 57.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it seemed that in the tumor cells, the PAX6 deletion extends more to 3?
Positive_regulation (extends) of Gene_expression (deletion) of PAX6 associated with cancer
1) Confidence 0.50 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 0.49 Pain Relevance 0
This insertion abolishes Pax6 DNA-binding properties [3] and seems to induce, when the Pax6(+5a) isoform is overexpressed, a developmental cascade modifying the neuronal architecture of the retina [4].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Pax6 in retina
2) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2649307 Disease Relevance 0.37 Pain Relevance 0
Furthermore, in combination with additional transcription factors, the level and spatial distribution of PAX6 expression in the developing eye are important for the establishment of the eye axes.
Positive_regulation (important) of Gene_expression (expression) of PAX6 in eye
3) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2649307 Disease Relevance 0.08 Pain Relevance 0.03
Despite robust MUSASHI and SOX1 expression, we found that addition of SB431542 failed to induce high levels of PAX6 expression (6.7±1% PAX6 positive cells at day 8 compared to 31.2±3.4% in control conditions, Fig. 2C).
Positive_regulation (levels) of Gene_expression (expression) of PAX6
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0 Pain Relevance 0
Despite robust MUSASHI and SOX1 expression, we found that addition of SB431542 failed to induce high levels of PAX6 expression (6.7±1% PAX6 positive cells at day 8 compared to 31.2±3.4% in control conditions, Fig. 2C).
Neg (failed) Positive_regulation (induce) of Gene_expression (expression) of PAX6
5) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0 Pain Relevance 0
These cells expressed transcription factors pdx-1, pax-6, and isl-1, all three are central controlling genes capable of reprogramming nonpancreatic cells to surrogate ?
Positive_regulation (factors) of Gene_expression (expressed) of pax-6
6) Confidence 0.30 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.25 Pain Relevance 0
This suggests that the expression of CK1/10 was down-regulated by the corneal stroma of the host animal during the process of corneal epithelium regeneration and that PAX-6 expression was upregulated.


Positive_regulation (upregulated) of Gene_expression (expression) of PAX-6 in corneal epithelium
7) Confidence 0.26 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426721 Disease Relevance 0.40 Pain Relevance 0

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