INT235840

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 91 99.90 Very High Very High Very High
fluoxetine 2 99.72 Very High Very High Very High
Dopamine 3 91.36 High High
Kinase C 15 72.64 Quite High
depression 34 68.80 Quite High
Nucleus accumbens 1 66.48 Quite High
antidepressant 39 62.84 Quite High
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 71.44 Quite High
Depression 40 68.80 Quite High
Manic Depressive Disorder 3 51.60 Quite High
Affective Disorder 12 10.56 Low Low
Stress 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Suicidal Behaviour 5 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy of fluoxetine, an SSRI, is diminished in mice that are lacking DARPP-32 (Svenningsson et al 2002).
Negative_regulation (diminished) of Neg (lacking) Gene_expression (lacking) of DARPP-32 associated with ssri and fluoxetine
1) Confidence 0.09 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.19 Pain Relevance 0.57

General Comments

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