INT235842

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.94
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mtap2) intracellular (Mtap2) protein complex (Mtap2)
cytoplasm (Mtap2)
Anatomy Link Frequency
neurons 2
tubule 1
Mtap2 (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 91 88.56 High High
Eae 12 87.20 High High
antidepressant 39 82.24 Quite High
depression 37 80.96 Quite High
gABA 1 52.60 Quite High
Abeta 3 50.00 Quite Low
Calcium channel 6 46.40 Quite Low
Hippocampus 26 9.04 Low Low
Kinase C 15 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Decapitation 3 88.76 High High
Cognitive Disorder 39 87.20 High High
Depression 43 80.96 Quite High
Disease 32 76.80 Quite High
Urological Neuroanatomy 10 75.88 Quite High
Suicidal Behaviour 5 68.96 Quite High
Affective Disorder 12 60.76 Quite High
Congenital Anomalies 9 59.28 Quite High
Anxiety Disorder 3 14.48 Low Low
Stress 6 13.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
m coronal sections using a cryostat (CM3050S, Leica, Heidelberg, Germany), and the slices were fixed with 4% paraformaldehyde and stained with a monoclonal antibody against phosphorylated NF-H, MAP2, synaptophysin or MBP.
Phosphorylation (phosphorylated) of MAP2
1) Confidence 0.52 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.26 Pain Relevance 0.04
Calpain-positive fluorescence in the cytosol of MAP2-positive neurons continuously increased at 2 h to 96 h after the treatment of A?
Phosphorylation (cytosol) of MAP2 in neurons
2) Confidence 0.51 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.15 Pain Relevance 0
By contrast, the expression level of calpastatin, an endogenous inhibitor of calpain, in the cytosol of MAP2-positive neurons continuously decreased at 2 h to 96 h after the treatment of A?
Phosphorylation (cytosol) of MAP2 in neurons
3) Confidence 0.51 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.12 Pain Relevance 0
As noted above, PKA can phosphorylate MAP2, decreasing micro-tubule assembly, and potentially affecting dendritic and synaptic growth (Nestler et al 1989; Miyamoto et al 1997).
Phosphorylation (phosphorylate) of MAP2 in tubule
4) Confidence 0.30 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.40 Pain Relevance 0.40

General Comments

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