INT235842

Context Info Confidence 0.52 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 0.94 Pain Relevance 0.44

cytoskeleton (Mtap2) intracellular (Mtap2) protein complex (Mtap2) cytoplasm (Mtap2)

Anatomy Link Frequency neurons 2 tubule 1 Mtap2 (Mus musculus)

Pain Link Frequency Relevance Heat sSRI 91 88.56 Eae 12 87.20 antidepressant 39 82.24 depression 37 80.96 gABA 1 52.60 Abeta 3 50.00 Calcium channel 6 46.40 Hippocampus 26 9.04 Kinase C 15 5.00 Neurotransmitter 10 5.00

Disease Link Frequency Relevance Heat Decapitation 3 88.76 Cognitive Disorder 39 87.20 Depression 43 80.96 Disease 32 76.80 Urological Neuroanatomy 10 75.88 Suicidal Behaviour 5 68.96 Affective Disorder 12 60.76 Congenital Anomalies 9 59.28 Anxiety Disorder 3 14.48 Stress 6 13.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

m coronal sections using a cryostat (CM3050S, Leica, Heidelberg, Germany), and the slices were fixed with 4% paraformaldehyde and stained with a monoclonal antibody against phosphorylated NF-H, MAP2, synaptophysin or MBP.

Phosphorylation (phosphorylated) of MAP2

1) Confidence 0.52 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.26 Pain Relevance 0.04

Calpain-positive fluorescence in the cytosol of MAP2-positive neurons continuously increased at 2 h to 96 h after the treatment of A?

Phosphorylation (cytosol) of MAP2 in neurons

2) Confidence 0.51 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.15 Pain Relevance 0

By contrast, the expression level of calpastatin, an endogenous inhibitor of calpain, in the cytosol of MAP2-positive neurons continuously decreased at 2 h to 96 h after the treatment of A?

Phosphorylation (cytosol) of MAP2 in neurons

3) Confidence 0.51 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.12 Pain Relevance 0

As noted above, PKA can phosphorylate MAP2, decreasing micro-tubule assembly, and potentially affecting dendritic and synaptic growth (Nestler et al 1989; Miyamoto et al 1997).

Phosphorylation (phosphorylate) of MAP2 in tubule

4) Confidence 0.30 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.40 Pain Relevance 0.40

General Comments

This test has worked.