INT235846

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 43 99.84 Very High Very High Very High
Hippocampus 20 79.12 Quite High
depression 50 77.52 Quite High
sSRI 91 63.08 Quite High
Nucleus accumbens 1 30.48 Quite Low
headache 4 5.68 Low Low
long-term potentiation 109 5.00 Very Low Very Low Very Low
Neurotransmitter 26 5.00 Very Low Very Low Very Low
Kinase C 15 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 86.84 High High
Cognitive Disorder 188 85.44 High High
Depression 56 77.52 Quite High
Congenital Anomalies 6 70.84 Quite High
Schizophrenia 12 64.72 Quite High
Targeted Disruption 32 61.20 Quite High
Aging 12 31.40 Quite Low
Leukemia 1 19.84 Low Low
Suicidal Behaviour 5 18.20 Low Low
Affective Disorder 12 10.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, four isoforms of PDE4 mRNA have been found; PDE4A, PDE4B, PDE4C, and PDE4D.
Transcription (found) of PDE4A
1) Confidence 0.30 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.36 Pain Relevance 0.17
For example, four isoforms of PDE4 mRNA have been found; PDE4A, PDE4B, PDE4C, and PDE4D.
Transcription (found) of PDE4
2) Confidence 0.30 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.37 Pain Relevance 0.17
Antidepressants affect transcription of PDE4 (Ye et al 2000; Miro et al 2002; Zhao et al 2003), and PDE4D may mediate some anti-depressant effects of rolipram in animal models (Zhang et al 2002).
Transcription (transcription) of PDE4 associated with antidepressant
3) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.15 Pain Relevance 0.33

General Comments

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