INT235847

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.42
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Adcy1) plasma membrane (Adcy1) nucleus (Adcy1)
Anatomy Link Frequency
AC2 1
Adcy1 (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 91 99.26 Very High Very High Very High
antidepressant 39 98.72 Very High Very High Very High
adenocard 5 88.40 High High
depression 34 64.80 Quite High
antagonist 27 53.60 Quite High
Kinase C 37 25.76 Quite Low
Calcium channel 6 25.04 Quite Low
gABA 1 11.68 Low Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 94.68 High High
Anxiety Disorder 3 94.08 High High
Depression 40 64.80 Quite High
Cardiovascular Disease 1 60.92 Quite High
Hypertension 1 48.88 Quite Low
Vomiting 1 14.08 Low Low
Affective Disorder 12 8.12 Low Low
Endometriosis (extended) 12 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After specific siRNA transfection into FPEP2 cells, quantitative real-time RT-PCR showed that AC1 and AC3 mRNA expressions were reduced by 76% and 70% respectively compared with scrambled sequence siRNA transfection (Fig. 3B).
Transcription (expressions) of AC1
1) Confidence 0.25 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.05
After 48 h of transfection the cells were subjected to RNA extraction for AC1 and AC3 mRNA expression analysis or serum-starved overnight in medium containing indomethacin (3 µg/ml) for cAMP assay.
Transcription (expression) of AC1
2) Confidence 0.19 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
Antidepressant treatment, including SSRIs, has been associated with increased transcription of AC1 (Jensen et al 2000). 5-HT1a activation decreases activity of neuronal AC2 (Albert et al 1999), and mice lacking AC8 exhibit altered stress-induced anxiety (Schaefer et al 2000).
Transcription (transcription) of AC1 in AC2 associated with stress, antidepressant, anxiety disorder and ssri
3) Confidence 0.18 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.42 Pain Relevance 0.44

General Comments

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