INT235849

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 39 99.98 Very High Very High Very High
depression 34 77.52 Quite High
sSRI 91 63.36 Quite High
Nucleus accumbens 1 30.48 Quite Low
Kinase C 15 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
monoamine 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 40 77.52 Quite High
Congenital Anomalies 6 71.12 Quite High
Leukemia 1 19.84 Low Low
Suicidal Behaviour 5 18.48 Low Low
Affective Disorder 12 10.28 Low Low
Stress 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antidepressants affect transcription of PDE4 (Ye et al 2000; Miro et al 2002; Zhao et al 2003), and PDE4D may mediate some anti-depressant effects of rolipram in animal models (Zhang et al 2002).
Regulation (affect) of Transcription (transcription) of PDE4 associated with antidepressant
1) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.15 Pain Relevance 0.33

General Comments

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