INT235853

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.98
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
amygdala 4
arm 2
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 132 100.00 Very High Very High Very High
antidepressant 41 99.80 Very High Very High Very High
agonist 20 97.56 Very High Very High Very High
Kappa opioid receptor 100 97.28 Very High Very High Very High
Dynorphin 99 94.00 High High
antagonist 27 87.92 High High
depression 50 84.32 Quite High
dexamethasone 46 81.76 Quite High
sSRI 91 77.84 Quite High
Opioid 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 115 99.64 Very High Very High Very High
Targeted Disruption 80 98.56 Very High Very High Very High
Depression 56 84.32 Quite High
Stress 236 80.00 Quite High
Affective Disorder 17 65.84 Quite High
Obesity 1 58.88 Quite High
Hyponatremia 25 57.28 Quite High
Adrenal Insufficiency 10 55.28 Quite High
Neurodegenerative Disease 4 24.32 Low Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observation suggest that the negative regulation of the CRH gene expression in PVN is mediated by SRC-1a.
Regulation (regulation) of Gene_expression (expression) of CRH gene
1) Confidence 0.51 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.20
In contrast, the circadian regulation of the CRH mRNA expression is recognized in the mammalian PVN (Kwak et al. 1992; Kwak et al. 1993).
Regulation (regulation) of Gene_expression (expression) of CRH mRNA
2) Confidence 0.51 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0
In any case, the precise mechanisms of these tissue-specific regulations of CRH gene expression by glucocorticoid have not been fully elucidated.
Regulation (regulations) of Gene_expression (expression) of CRH gene
3) Confidence 0.51 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.33 Pain Relevance 0.09
On the contrary, as mentioned above, the stimulating (or at least, nonsuppressible) effect on the CRH gene expression by glucocorticoid in the amygdala is probably due to the different expression pattern of SRCs.
Regulation (effect) of Gene_expression (expression) of CRH gene in amygdala associated with amygdala
4) Confidence 0.37 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.19
Aside from this, other investigators report that the CRH gene expression in the amygdala is unchangeable by glucocorticoid (Kasckow et al. 1997).
Neg (unchangeable) Regulation (unchangeable) of Gene_expression (expression) of CRH gene in amygdala associated with amygdala
5) Confidence 0.37 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.21 Pain Relevance 0.10
Antidepressants also can alter the synthesis and release of CRH, thereby normalizing the HPA axis (Brady et al 1991; Torres et al 1998).
Regulation (alter) of Gene_expression (synthesis) of CRH associated with antidepressant
6) Confidence 0.36 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.44 Pain Relevance 0.49
In contrast, the selective CRF2-R agonist urocortin III did not affect open arm time, and mice lacking CRF2-R still showed an increase in anxiety-like behavior in response to CRF injection.
Regulation (response) of Gene_expression (injection) of CRF in arm associated with anxiety disorder and agonist
7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.77 Pain Relevance 0.87
We then measured CRF-induced EPM behavior and changes in KORp-ir.
Regulation (changes) of Gene_expression (behavior) of CRF-induced
8) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.23 Pain Relevance 0.72

General Comments

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