INT235868

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.21
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Atf6b) DNA binding (Creb1, Atf6b) mitochondrion (Creb1)
endoplasmic reticulum (Atf6b) intracellular (Atf6b) transcription factor binding (Creb1)
Creb1 (Mus musculus)
Atf6b (Mus musculus)
Pain Link Frequency Relevance Heat
depression 34 99.08 Very High Very High Very High
antidepressant 39 96.24 Very High Very High Very High
sSRI 91 93.36 High High
Nucleus accumbens 1 66.96 Quite High
Dopamine 3 16.48 Low Low
Kinase C 15 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
monoamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 40 99.08 Very High Very High Very High
Congenital Anomalies 6 57.44 Quite High
Leukemia 1 56.32 Quite High
Affective Disorder 12 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Suicidal Behaviour 5 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CREB is a member of the leucine zipper family of transcription factors, activating or repressing multiple genes with the cAMP response element (CRE) promoter (Yamamoto et al 1988).
CREB Negative_regulation (repressing) of cAMP response element
1) Confidence 0.02 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.21 Pain Relevance 0.40

General Comments

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