INT23588

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.44
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CCR1) plasma membrane (CCR1) cell-cell signaling (CCR1)
signal transducer activity (CCR1)
Anatomy Link Frequency
macrophage 1
monocyte 1
Liver 1
CCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 43 100.00 Very High Very High Very High
chemokine 42 100.00 Very High Very High Very High
Central nervous system 3 100.00 Very High Very High Very High
cytokine 13 99.90 Very High Very High Very High
Multiple sclerosis 82 98.24 Very High Very High Very High
Chronic pancreatitis 4 96.92 Very High Very High Very High
Inflammatory response 2 86.80 High High
aspirin 10 75.00 Quite High
cINOD 3 72.68 Quite High
abdominal pain 1 66.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 47 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Encephalopathy 9 99.18 Very High Very High Very High
Multiple Sclerosis 93 98.24 Very High Very High Very High
Hepatotoxicity 2 97.86 Very High Very High Very High
Pancreatic Cancer 4 97.80 Very High Very High Very High
Pancreatitis 6 96.92 Very High Very High Very High
Disorders Of Creatine Metabolism 6 94.36 High High
Disease 34 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liver damage seems to play a role in increasing serum IRT levels of patients without pancreatic involvement, while the increased Ctr/Ccr seems to depend on other factors, for instance renal tubular dysfunction.
Positive_regulation (increased) of Ccr in Liver associated with hepatotoxicity
1) Confidence 0.67 Published 1985 Journal Ric Clin Lab Section Abstract Doc Link 2422720 Disease Relevance 0.87 Pain Relevance 0.16
These findings indicate that the inhibitory effects of evodiamine and rutaecarpine on LIGHT-induced migration and the activation of CCR1, CCR2, ICAM-1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
Positive_regulation (activation) of CCR1
2) Confidence 0.58 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.26 Pain Relevance 0.17
Elevated Ctr/Ccr and IRT values were observed in several patients with pancreatic cancer and chronic pancreatitis.
Positive_regulation (Elevated) of Ccr associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.21 Published 1985 Journal Ric Clin Lab Section Abstract Doc Link 2422720 Disease Relevance 0.96 Pain Relevance 0.19
At least one novel drug is in the pipeline which targets CCR1 (another receptor for CCL5) for therapy of MS and other inflammatory disorders [79].
Positive_regulation (targets) of CCR1 associated with chemokine, multiple sclerosis and inflammation
4) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.58 Pain Relevance 0.74
In parallel experiments involving human colonic mucosa ex vivo, LXA(4)potently attenuated TNF-alpha-stimulated release of the C-X-C chemokine IL-8, and the C-C chemokines monocyte-chemoattractant protein-1 (MCP-1) and RANTES.
Positive_regulation (attenuated) of RANTES in monocyte associated with chemokine
5) Confidence 0.08 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11509622 Disease Relevance 0.51 Pain Relevance 0.55
Following the development of the PTRE in this model a number of cytokines are increased within the CNS including tumour necrosis factor (TNF) alpha, interleukins 1, 4 and 6, and macrophage inflammatory protein (MIP)-1.
Positive_regulation (increased) of inflammatory protein in macrophage associated with necrosis, inflammation, cancer, encephalopathy, central nervous system and cytokine
6) Confidence 0.06 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10695713 Disease Relevance 1.27 Pain Relevance 0.43

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