INT235881

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca, Creb1) nucleus (Prkaca, Creb1) Golgi apparatus (Prkaca)
DNA binding (Creb1) protein complex (Prkaca) cytoplasm (Prkaca)
Anatomy Link Frequency
nucleus 1
Prkaca (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 32 94.88 High High
depression 34 93.12 High High
antidepressant 39 92.36 High High
sSRI 91 72.48 Quite High
Nucleus accumbens 1 46.08 Quite Low
Hippocampus 10 32.56 Quite Low
Kinase C 15 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 40 93.12 High High
Congenital Anomalies 6 63.52 Quite High
Leukemia 1 35.44 Quite Low
Suicidal Behaviour 5 10.88 Low Low
Targeted Disruption 19 5.00 Very Low Very Low Very Low
Affective Disorder 12 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Fever 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As noted, CREB is directly activated by PKA.
PKA Positive_regulation (activated) of CREB
1) Confidence 0.10 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.16 Pain Relevance 0.36
Consequently, cAMP activates cAMP-dependent protein kinase (PKA), which may in turn activate cAMP response element binding protein (CREB), a transcription factor, in the nucleus.
PKA Positive_regulation (activate) of CREB in nucleus
2) Confidence 0.03 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.28

General Comments

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