INT235882

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
brain 2
Creb1 (Mus musculus)
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 1 96.72 Very High Very High Very High
antidepressant 39 93.08 High High
sSRI 91 83.04 Quite High
depression 34 72.92 Quite High
Dopamine 3 69.52 Quite High
fluoxetine 2 53.52 Quite High
Kinase C 15 20.72 Low Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 100.00 Very High Very High Very High
Depression 40 72.92 Quite High
Congenital Anomalies 6 31.28 Quite Low
Affective Disorder 12 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Suicidal Behaviour 5 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CREB also increases BCL-2 (B-cell leukemia-2) expression (Riccio et al 1999) and is necessary for the increased brain-derived neurotrophic factor (BDNF).
CREB Positive_regulation (necessary) of Positive_regulation (increased) of BDNF in brain associated with leukemia
1) Confidence 0.11 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.17 Pain Relevance 0.47

General Comments

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