INT235885

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkca, Slc6a4) plasma membrane (Prkca, Slc6a4) endosome (Slc6a4)
transport (Slc6a4) mitochondrion (Prkca) endoplasmic reticulum (Prkca)
Prkca (Mus musculus)
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 15 100.00 Very High Very High Very High
long-term potentiation 3 90.32 High High
Central nervous system 1 88.36 High High
sSRI 91 83.44 Quite High
Hippocampus 2 79.68 Quite High
antidepressant 39 62.60 Quite High
depression 34 49.60 Quite Low
Neurotransmitter 10 32.40 Quite Low
fluoxetine 2 31.28 Quite Low
Calcium channel 6 24.72 Low Low
Disease Link Frequency Relevance Heat
Affective Disorder 12 78.88 Quite High
Manic Depressive Disorder 3 58.44 Quite High
Depression 40 49.60 Quite Low
Stress 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Suicidal Behaviour 5 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKC also desensitizes 5-HT2A receptors (Rahimian and Hrdina 1995) and downregulates SERT (Ramamoorthy et al 1998).
PKC Negative_regulation (downregulates) of SERT associated with kinase c
1) Confidence 0.05 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.14 Pain Relevance 0.49

General Comments

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