INT235907

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.93
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rtn4) aging (Rtn4) endoplasmic reticulum (Rtn4)
plasma membrane (Rtn4) protein complex (Rtn4) cytoplasm (Rtn4)
Anatomy Link Frequency
neurons 4
Rtn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 237 99.82 Very High Very High Very High
dorsal root ganglion 219 99.66 Very High Very High Very High
addiction 21 85.60 High High
sodium channel 51 65.68 Quite High
hyperexcitability 60 60.96 Quite High
Root ganglion neuron 3 50.00 Quite Low
nav1.8 39 40.16 Quite Low
Nav1.9 21 39.28 Quite Low
Nav1.7 30 35.52 Quite Low
Nav1.6 6 34.88 Quite Low
Disease Link Frequency Relevance Heat
Injury 270 99.82 Very High Very High Very High
Ganglion Cysts 231 99.66 Very High Very High Very High
Nervous System Injury 54 81.08 Quite High
Nociception 15 47.84 Quite Low
INFLAMMATION 21 21.20 Low Low
Targeted Disruption 9 11.36 Low Low
Neuropathic Pain 42 5.00 Very Low Very Low Very Low
Hyperalgesia 33 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both CCD- and CCI-induced reduction in TTX-R current densities are unchanged in this analysis (Fig. 4B).
Neg (unchanged) Regulation (unchanged) of Negative_regulation (reduction) of TTX-R associated with eae
1) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.85 Pain Relevance 0.43
Neither CCD nor CCI treatment significantly altered inactivation of both TTX-R and TTX-S currents in the slow neurons (Table 3).


Neg (Neither) Regulation (altered) of Negative_regulation (inactivation) of TTX-R in neurons associated with eae
2) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.95 Pain Relevance 0.43
The principle findings are 1) CCD treatment significantly reduces the TTX-R and TTX-S current densities in the small-slow and small-fast subtypes of DRG neurons; 2) CCD alters voltage-dependent steady-state inactivation of the TTX-R and TTX-S currents and increases window current of the activation and inactivation, but exhibits different effects on V1/2 and k of the TTX-S currents in both slow and fast neurons; 3) CCD reduces the decay rates of the TTX-S, but not TTX-R currents inactivation in the fast neurons; and 4) CCI shows different effects from CCD in most of the tested properties of the TTX-R and TTX-S currents.
Regulation (alters) of Negative_regulation (inactivation) of TTX-R in neurons associated with dorsal root ganglion and eae
3) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 1.13 Pain Relevance 0.56

General Comments

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