INT235939

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.70
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp5) endoplasmic reticulum (Aqp5) plasma membrane (Aqp5)
transmembrane transport (Aqp5)
Anatomy Link Frequency
neuronal 1
exocrine glands 1
neurons 1
epithelium 1
corneal epithelium 1
Aqp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 115 98.68 Very High Very High Very High
Spinal cord 61 91.84 High High
Pain 29 83.28 Quite High
cocaine 3 76.48 Quite High
Hippocampus 6 75.60 Quite High
Nucleus accumbens 1 73.52 Quite High
amygdala 1 72.76 Quite High
Inflammation 45 71.68 Quite High
Ventral tegmentum 1 71.52 Quite High
midbrain 7 71.48 Quite High
Disease Link Frequency Relevance Heat
Salivary Gland Disease 5 99.84 Very High Very High Very High
Pressure And Volume Under Development 48 99.72 Very High Very High Very High
Disorders Of The Lacrimal System 5 99.44 Very High Very High Very High
Convulsion 5 99.40 Very High Very High Very High
Autoimmune Disease 25 96.86 Very High Very High Very High
Syndrome 11 96.36 Very High Very High Very High
Hypoxia 15 94.56 High High
Infection 63 90.72 High High
Disease 105 88.76 High High
Neuromyelitis Optica 215 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, an extensive network of AQP, including AQP5 expression, is present in the OE [11].
Gene_expression (expression) of AQP5
1) Confidence 0.45 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.08 Pain Relevance 0.12
As the gastric aquaporin Aqp5 is expressed on the lateral and intercellular membranes in the gastric crypts [59], we speculate that this pore is influenced by changes to tight junction proteins, and that it plays a role in the development of oedema in the epithelium during infection.
Gene_expression (expressed) of Aqp5 in epithelium associated with pressure and volume under development and infection
2) Confidence 0.44 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.45 Pain Relevance 0.03
Reverse transcription-polymerase chain reaction showed expression of AQP3, AQP5 and AQP8 in neuronal primary cultures and astrocyte cultures.
Gene_expression (expression) of AQP5 in neuronal
3) Confidence 0.33 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.27 Pain Relevance 0.19
AQP5 is permeable to water and expressed in glandular epithelia, corneal epithelium, alveolar epithelium and gastrointestinal tract [95].
Gene_expression (expressed) of AQP5 in corneal epithelium
4) Confidence 0.33 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.64 Pain Relevance 0.10
AQP8 expression was also found in neurons and oligodendrocytes whereas AQP5 expression was only found in neurons [143].
Gene_expression (expression) of AQP5 in neurons
5) Confidence 0.31 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.24 Pain Relevance 0.04
The subgroup of aquaporins is composed of AQP0, AQP1, AQP2, AQP4, AQP5, AQP6 and AQP8 and is considered to be mainly permeable to water with a high flow rate.
Gene_expression (composed) of AQP5
6) Confidence 0.28 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0
The presence of AQP3, AQP5, and AQP8, AQP9 was reported in central nervous system (CNS) [39], but their physiological role has not been fully analyzed.


Spec (analyzed) Gene_expression (presence) of AQP5 in central nervous system associated with central nervous system
7) Confidence 0.21 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.44 Pain Relevance 0.43
AQP8 expression was also found in neurons and oligodendrocytes whereas AQP5 expression was only found in neurons [143].
Gene_expression (expression) of AQP5 in oligodendrocytes
8) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.24 Pain Relevance 0.04
Sjögren's Syndrome is an autoimmune disease characterized by inadequate tear and saliva production and a lymphocyte infiltration of exocrine glands, especially the lacrimal and salivary glands, which express AQP 5 on the apical membrane and AQP4 on lateral membranes [97,98].
Gene_expression (express) of AQP 5 in exocrine glands associated with disorders of the lacrimal system, autoimmune disease, salivary gland disease and syndrome
9) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.33 Pain Relevance 0.13

General Comments

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